Diagnostic PANoptosis-related genes in acute kidney injury: bioinformatics, machine learning, and validation.

Journal: Annals of medicine
Published Date: Sep 2, 2025

Abstract

BACKGROUND: Acute kidney injury (AKI) is a prevalent and life-threatening condition characterized by abrupt renal function decline and subsequent inflammatory cascades. PANoptosis has emerged as a significant contributor to the pathophysiology of AKI. This research aimed to explore the diagnostic and therapeutic implications of PANoptosis-related genes in AKI.

Authors

  • Zhen Chen
    School of Basic Medicine, Qingdao University, Qingdao 266021, China.
  • Xiaogang Wang
    Department of Mathematics and Statistics, York University, Toronto, ON, Canada.
  • Yifan Shao
    School of Computer Science and Technology, Soochow University, Suzhou, China.
  • Kai Wang
    Department of Rheumatology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.
  • Dong Xue
    Departments of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.

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