Use of Machine Learning to Determine Deviance in Neuroanatomical Maturity Associated With Future Psychosis in Youths at Clinically High Risk.

Journal: JAMA psychiatry
Published Date:

Abstract

IMPORTANCE: Altered neurodevelopmental trajectories are thought to reflect heterogeneity in the pathophysiologic characteristics of schizophrenia, but whether neural indicators of these trajectories are associated with future psychosis is unclear.

Authors

  • Yoonho Chung
    Department of Psychology, Yale University, New Haven, Connecticut.
  • Jean Addington
    Department of Psychiatry, University of Calgary, Calgary, AB, Canada.
  • Carrie E Bearden
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States.
  • Kristin Cadenhead
    Department of Psychiatry, University of California, San Diego, La Jolla.
  • Barbara Cornblatt
    Department of Psychiatry, Zucker Hillside Hospital, Queens, New York.
  • Daniel H Mathalon
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA, United States.
  • Thomas McGlashan
    Department of Psychiatry, Yale University, New Haven, Connecticut.
  • Diana Perkins
    Department of Psychiatry, University of North Carolina, Chapel Hill.
  • Larry J Seidman
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
  • Ming Tsuang
    Department of Psychiatry, University of California, San Diego, La Jolla.
  • Elaine Walker
    Department of Psychology, Emory University, Atlanta, Georgia.
  • Scott W Woods
    Department of Psychology, Yale University, New Haven, CT, United States.
  • Sarah McEwen
    Semel Institute for Neuroscience and Human Behavior, Department of Psychology, University of California, Los Angeles.
  • Theo G M van Erp
    Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.
  • Tyrone D Cannon
    Department of Psychology, Yale University, New Haven, CT, United States.