LUADpp: an effective prediction model on prognosis of lung adenocarcinomas based on somatic mutational features.

Journal: BMC cancer
Published Date: Mar 22, 2019

Abstract

BACKGROUND: Lung adenocarcinoma is the most common type of lung cancers. Whole-genome sequencing studies disclosed the genomic landscape of lung adenocarcinomas. however, it remains unclear if the genetic alternations could guide prognosis prediction. Effective genetic markers and their based prediction models are also at a lack for prognosis evaluation.

Authors

  • Jiaxian Yu
    Department of Cardiovascular Diseases, First Affiliated Hospital, Hunan University of Medicine, Huaihua 418000, China.
  • Yueming Hu
    Youth Innovation Team of Medical Bioinformatics, Shenzhen University Health Science Center, Shenzhen, China.
  • Yafei Xu
    Department of Cell Biology and Genetics, Shenzhen University Health Science Center, Shenzhen, 518060, China.
  • Jue Wang
    State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau SAR, China.
  • Jiajie Kuang
    Department of Cell Biology and Genetics, Shenzhen University Health Science Center, Shenzhen, 518060, China.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.
  • Jianlin Shao
  • Dianjing Guo
    State Key Laboratory of Agrobiotechnology and School of Life Science, The Chinese University of Hong Kong, Shatin, Hong Kong, China. djguo@cuhk.edu.hk.
  • Yejun Wang
    Youth Innovation Team of Medical Bioinformatics, Shenzhen University Health Science Center, Shenzhen, China.

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