Pathologist-level classification of histopathological melanoma images with deep neural networks.

Journal: European journal of cancer (Oxford, England : 1990)
Published Date: May 23, 2019

Abstract

BACKGROUND: The diagnosis of most cancers is made by a board-certified pathologist based on a tissue biopsy under the microscope. Recent research reveals a high discordance between individual pathologists. For melanoma, the literature reports 25-26% of discordance for classifying a benign nevus versus malignant melanoma. Deep learning was successfully implemented to enhance the precision of lung and breast cancer diagnoses. The aim of this study is to illustrate the potential of deep learning to assist human assessment for a histopathologic melanoma diagnosis.

Authors

  • Achim Hekler
    National Center for Tumor Diseases, Department of Translational Oncology, German Cancer Research Center, Heidelberg, Germany.
  • Jochen Sven Utikal
    Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany.
  • Alexander H Enk
    Department of Dermatology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
  • Carola Berking
    Department of Dermatology, University Hospital Munich, Ludwig Maximilian University of Munich, Munich, Germany.
  • Joachim Klode
    Department of Dermatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
  • Dirk Schadendorf
    Department of Dermatology, University Hospital Essen, 45147 Essen, Germany.
  • Philipp Jansen
    Department of Dermatology, University Hospital Essen, Essen, Germany.
  • Cindy Franklin
    Department of Dermatology, University Hospital Cologne, Cologne, Germany.
  • Tim Holland-Letz
    Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany.
  • Dieter Krahl
    Private Laboratory of Dermatohistopathology, Mönchhofstraße 52, 69120 Heidelberg.
  • Christof von Kalle
    National Center for Tumor Diseases, Department of Translational Oncology, German Cancer Research Center, Heidelberg, Germany.
  • Stefan Fröhling
    National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.
  • Titus Josef Brinker
    National Center for Tumor Diseases, Department of Translational Oncology, German Cancer Research Center, Heidelberg, Germany.

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