Effect of Radiation Doses to the Heart on Survival for Stereotactic Ablative Radiotherapy for Early-stage Non-Small-cell Lung Cancer: An Artificial Neural Network Approach.

Journal: Clinical lung cancer
PMID: 31932217

Abstract

INTRODUCTION: The cardiac radiation dose is an important predictor of cardiac toxicity and overall survival (OS) for patients with locally advanced non-small-cell lung cancer (NSCLC). However, radiation-induced cardiac toxicity among patients with early-stage NSCLC who have undergone stereotactic ablative radiotherapy (SABR) has been less well-characterized. Our objective was to assess the associations between cardiac radiation dosimetry and OS in patients with early-stage NSCLC undergoing SABR.

Authors

  • Shawna T Chan
    Department of Radiation Oncology, University of California, Los Angeles, School of Medicine, Los Angeles, CA; University of California, Irvine, School of Medicine, Irvine, CA.
  • Dan Ruan
    Departments of Radiation Oncology, Biomedical Physics and Bioengineering, UCLA, Los Angeles, CA, 90095, USA.
  • Narek Shaverdian
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California. Electronic address: nshaverdian@mednet.ucla.edu.
  • Govind Raghavan
    Department of Radiation Oncology, University of California, Los Angeles, School of Medicine, Los Angeles, CA.
  • Minsong Cao
    Department of Radiation Oncology, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
  • Percy Lee
    Department of Radiation Oncology, University of California Los Angeles, Los Angeles, California.

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