Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research
Published Date: Oct 21, 2019

Abstract

PURPOSE: Biomarkers for disease-specific survival (DSS) in early-stage melanoma are needed to select patients for adjuvant immunotherapy and accelerate clinical trial design. We present a pathology-based computational method using a deep neural network architecture for DSS prediction.

Authors

  • Prathamesh M Kulkarni
    Department of Psychiatry, School of Medicine, New York University, New York, NY 10016, United States of America.
  • Eric J Robinson
  • Jaya Sarin Pradhan
    Department of Medicine, Columbia University Irving Medical Center, New York, New York.
  • Robyn D Gartrell-Corrado
    Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.
  • Bethany R Rohr
    Department of Pathology, Geisinger Health System, Danville, Pennsylvania.
  • Megan H Trager
    Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.
  • Larisa J Geskin
    Department of Dermatology, Columbia University Irving Medical Center, New York, New York.
  • Harriet M Kluger
    Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
  • Pok Fai Wong
    Department of Pathology, Yale School of Medicine, New Haven, Connecticut.
  • Balazs Acs
    Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden; Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.
  • Emanuelle M Rizk
    Department of Medicine, Columbia University Irving Medical Center, New York, New York.
  • Chen Yang
    Department of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.
  • Manas Mondal
    Department of Medicine, Columbia University Irving Medical Center, New York, New York.
  • Michael R Moore
    Department of Medicine, Columbia University Irving Medical Center, New York, New York.
  • Iman Osman
    Departments of Dermatology, Medicine, and Urology, NYU School of Medicine, New York, New York.
  • Robert Phelps
    Departments of Pathology and Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Basil A Horst
    Department of Pathology, University of British Columbia, Vancouver, Canada.
  • Zhe S Chen
    Department of Psychiatry, School of Medicine, NYU School of Medicine, New York, New York.
  • Tammie Ferringer
    Department of Pediatrics, Columbia University Irving Medical Center, New York, New York.
  • David L Rimm
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
  • Jing Wang
    Endoscopy Center, Peking University Cancer Hospital and Institute, Beijing, China.
  • Yvonne M Saenger
    Department of Medicine, Columbia University Irving Medical Center, New York, New York. yms4@cumc.columbia.edu jing.wang2@nyulangone.org.

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