Cognitive signature of brain FDG PET based on deep learning: domain transfer from Alzheimer's disease to Parkinson's disease.

Journal: European journal of nuclear medicine and molecular imaging
Published Date: Nov 25, 2019

Abstract

PURPOSE: Although functional brain imaging has been used for the early and objective assessment of cognitive dysfunction, there is a lack of generalized image-based biomarker which can evaluate individual's cognitive dysfunction in various disorders. To this end, we developed a deep learning-based cognitive signature of FDG brain PET adaptable for Parkinson's disease (PD) as well as Alzheimer's disease (AD).

Authors

  • Hongyoon Choi
    Cheonan Public Health Center, 234-1 Buldang-Dong, Seobuk-Gu, Cheonan, Republic of Korea.
  • Yu Kyeong Kim
    Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
  • Eun Jin Yoon
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea.
  • Jee-Young Lee
    Department of Neurology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, 07061, Republic of Korea. wieber04@snu.ac.kr.
  • Dong Soo Lee
    Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

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