Multifactorial Deep Learning Reveals Pan-Cancer Genomic Tumor Clusters with Distinct Immunogenomic Landscape and Response to Immunotherapy.

Abstract

Authors

• Feng Xie
  School of Computer Science, Guangdong University of Technology, Guangzhou, China. Electronic address: 1111705006@mail2.gdut.edu.cn.
• Jianjun Zhang
  Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, Houston, Texas, USA.
• Jiayin Wang
  MicroPort(Shanghai) MedBot Co. Ltd, Shanghai, 200031.
• Alexandre Reuben
  Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
• Wei Xu
  College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, 471023 China.
• Xin Yi
  Shanghai Wision AI Co., Ltd, Shanghai, China.
• Frederick S Varn
  Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
• Yongsheng Ye
  School of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China.
• Junwen Cheng
  School of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China.
• Miao Yu
  Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China; School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, China; Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519087, China.
• Yue Wang
  Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
• Yufeng Liu
  Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
• Mingchao Xie
  School of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China.
• Peng Du
  Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
• Ke Ma
  Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology Shanghai 200083 China yangfyhit@sina.com +86 021 22028363 +86 021 22028362.
• Xin Ma
  Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
• Penghui Zhou
  State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China.
• Shengli Yang
  Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• Yaobing Chen
  Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• Guoping Wang
  School of Electronic Information and Communications, Huazhong University of Science and Technology, Wuhan, China.
• Xuefeng Xia
  Genomic Medicine, The Methodist Hospital Research Institute, Houston, Texas.
• Zhongxing Liao
  Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
• John V Heymach
  Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
• Ignacio I Wistuba
  Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.
• P Andrew Futreal
  Department of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas, USA.
• Kai Ye
  MandalaT Software Corporation, F5, Wuxi, China.
• Chao Cheng
  Department of Molecular and Systems Biology, Lebanon, USA. Chao.Cheng@bcm.edu.
• Tian Xia
  National Center of Biomedical Analysis, Beijing 100850, China.

Keywords

External Resources