Machine Learning of 12-Lead QRS Waveforms to Identify Cardiac Resynchronization Therapy Patients With Differential Outcomes.

Journal: Circulation. Arrhythmia and electrophysiology
PMID: 32538136

Abstract

BACKGROUND: Cardiac resynchronization therapy (CRT) improves heart failure outcomes but has significant nonresponse rates, highlighting limitations in ECG selection criteria: QRS duration (QRSd) ≥150 ms and subjective labeling of left bundle branch block (LBBB). We explored unsupervised machine learning of ECG waveforms to identify CRT subgroups that may differentiate outcomes beyond QRSd and LBBB.

Authors

  • Albert K Feeny
    Cleveland Clinic Lerner College of Medicine (A.K.F., M.A.L.), Case Western Reserve University, OH.
  • John Rickard
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.
  • Kevin M Trulock
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.
  • Divyang Patel
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.
  • Saleem Toro
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.
  • Laurie Ann Moennich
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., K.M.T., D.P., S.T., L.A.M., N.V., M.J.N., E.Z.G.), Cleveland Clinic, OH.
  • Niraj Varma
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.
  • Mark J Niebauer
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.
  • Eiran Z Gorodeski
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.
  • Richard A Grimm
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.
  • John Barnard
    Department of Quantitative Health Sciences, Lerner Research Institute (X.J., J.B.), Cleveland Clinic, OH.
  • Anant Madabhushi
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.
  • Mina K Chung
    Department of Cardiovascular Medicine, Heart and Vascular Institute (J.R., D.P., S.T., K.M.T., N.V., M.J.N., E.Z.G., R.A.G., M.K.C.), Cleveland Clinic, OH.

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