Accurate detection of spontaneous seizures using a generalized linear model with external validation.

Journal: Epilepsia
Published Date: Sep 1, 2020

Abstract

OBJECTIVE: Seizure detection is a major facet of electroencephalography (EEG) analysis in neurocritical care, epilepsy diagnosis and management, and the instantiation of novel therapies such as closed-loop stimulation or optogenetic control of seizures. It is also of increased importance in high-throughput, robust, and reproducible pre-clinical research. However, seizure detectors are not widely relied upon in either clinical or research settings due to limited validation. In this study, we create a high-performance seizure-detection approach, validated in multiple data sets, with the intention that such a system could be available to users for multiple purposes.

Authors

  • Nicolas F Fumeaux
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Senan Ebrahim
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Brian F Coughlin
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Adesh Kadambi
  • Aafreen Azmi
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Jen X Xu
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Maurice Abou Jaoude
    Epilepsy Division, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Sunil B Nagaraj
    1Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.2Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.3Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.4Department of Electronics, Informatics and Bioengineering, Politecnico di Milano, Milan, Italy.
  • Kyle E Thomson
    Department of Pharmacology, University of Utah, Salt Lake City, UT, USA.
  • Thomas G Newell
    Department of Pharmacology, University of Utah, Salt Lake City, UT, USA.
  • Cameron S Metcalf
    Department of Pharmacology, University of Utah, Salt Lake City, UT, USA.
  • Karen S Wilcox
    Department of Pharmacology, University of Utah, Salt Lake City, UT, USA.
  • Eyal Y Kimchi
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Marcio F D Moraes
    Nucleo de Neurociencias, Universidade Federal de Minas Gerais, Brazil.
  • Sydney S Cash
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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