AIMC Topic: Kainic Acid

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Accurate detection of spontaneous seizures using a generalized linear model with external validation.

Epilepsia Aug 6, 2020
OBJECTIVE: Seizure detection is a major facet of electroencephalography (EEG) analysis in neurocritical care, epilepsy diagnosis and management, and the instantiation of novel therapies such as closed-loop stimulation or optogenetic control of seizur...
Machine Learning Reproducibility of Results Animals ROC Curve Rats Disease Models, Animal Area Under Curve Electroencephalography Seizures Signal Processing, Computer-Assisted Linear Models Epilepsies, Partial Electrocorticography Kainic Acid Excitatory Amino Acid Agonists
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Bursts with High and Low Load of Epileptiform Spikes Show Context-Dependent Correlations in Epileptic Mice.

eNeuro Sep 5, 2019
Hypersynchronous network activity is the defining hallmark of epilepsy and manifests in a wide spectrum of phenomena, of which electrographic activity during seizures is only one extreme. The aim of this study was to differentiate between different t...
Machine Learning Animals Male Mice Action Potentials Mice, Inbred C57BL Electroencephalography Epilepsy Hippocampus Kainic Acid
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Novel predictive approaches for drug-induced convulsions in non-human primates using machine learning and heart rate variability analysis.

The Journal of toxicological sciences Jan 1, 2024
Drug-induced convulsions are a major challenge to drug development because of the lack of reliable biomarkers. Using machine learning, our previous research indicated the potential use of an index derived from heart rate variability (HRV) analysis in...
Machine Learning Biomarkers Animals Male Electrocardiography Dose-Response Relationship, Drug Seizures Heart Rate Telemetry Bupropion Autonomic Nervous System Convulsants Kainic Acid 4-Aminopyridine Ranolazine
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