Machine learning analysis of DNA methylation in a hypoxia-immune model of oral squamous cell carcinoma.

Journal: International immunopharmacology
Published Date:

Abstract

BACKGROUND: Hypoxia status and immunity are related with the development and prognosis of oral squamous cell carcinoma (OSCC). Here, we constructed a hypoxia-immune model to explore its upstream mechanism and identify potential CpG sites.

Authors

  • Hao Zeng
    European Laboratory for Non Linear Spectroscopy (LENS), University of Florence, 50019 Sesto Fiorentino, Italy.
  • Meng Luo
    Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, China; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.
  • Linyan Chen
    Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, China; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.
  • Xinyu Ma
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.
  • Xuelei Ma