Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.

Journal: Pharmacological reports : PR
PMID: 32048249

Abstract

BACKGROUND: Anesthesia is a major component of surgery and recently considered an important regulator of cell phenotypes. Here we aimed to investigate propofol, an anesthesia drug, in suppressing pancreatic cancer (PDAC), focusing on A disintegrin and metalloprotease 8, (ADAM8) as a molecular mediator.

Authors

  • Xiangdi Yu
    Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, 550003, China. xiangdi_yu@sina.com.
  • Jinshan Shi
    Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, 550003, China.
  • Xin Wang
    Key Laboratory of Bio-based Material Science & Technology (Northeast Forestry University), Ministry of Education, Harbin 150040, China.
  • Fangxiang Zhang
    Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, 550003, China.

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