AIMC Topic: Matrix Metalloproteinase 2

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Construction of a deep learning-based predictive model to evaluate the influence of mechanical stretching stimuli on MMP-2 gene expression levels in fibroblasts.

Biomedical engineering online Jun 5, 2025
BACKGROUND: Matrix metalloproteinase-2 (MMP-2) secretion homeostasis, governed by the multifaceted interplay of skin stretching, is a pivotal determinant influencing wound healing dynamics. This investigation endeavors to devise an artificial intelli...
Humans Fibroblasts Matrix Metalloproteinase 2 Stress, Mechanical Mechanical Phenomena Biomechanical Phenomena Animals Deep Learning
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The effect of thalidomide on the invasive ability of gastric cancer cells by regulating miR-524-5p/FSTL1.

Cellular and molecular biology (Noisy-le-Grand, France) Dec 20, 2023
This study aimed to investigate the effect of thalidomide (Thal) regulating microRNA (miR)-524-5p/follistatin-like protein 1 (FSTL1) on the invasion ability of gastric cancer cells. For this purpose, real-time fluorescent quantitative PCR (RT-qPCR) w...
Matrix Metalloproteinase 9 Luciferases Follistatin-Related Proteins Humans Cell Proliferation Matrix Metalloproteinase 2 Stomach Neoplasms Cell Movement Cell Line, Tumor MicroRNAs Thalidomide
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A disease network-based deep learning approach for characterizing melanoma.

International journal of cancer Nov 17, 2021
Multiple types of genomic variations are present in cutaneous melanoma and some of the genomic features may have an impact on the prognosis of the disease. The access to genomics data via public repositories such as The Cancer Genome Atlas (TCGA) all...
Female Melanoma Skin Neoplasms Aged Humans Matrix Metalloproteinase 2 Receptor, ErbB-3 Middle Aged Deep Learning Genomics Signal Transduction Young Adult Adult Male
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Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.

Pharmacological reports : PR Dec 20, 2019
BACKGROUND: Anesthesia is a major component of surgery and recently considered an important regulator of cell phenotypes. Here we aimed to investigate propofol, an anesthesia drug, in suppressing pancreatic cancer (PDAC), focusing on A disintegrin an...
Propofol Cell Movement Apoptosis Neoplasm Invasiveness Cell Line, Tumor Mice, SCID Xenograft Model Antitumor Assays Membrane Proteins Humans Pancreatic Neoplasms Neoplasm Metastasis Matrix Metalloproteinase 9 Cell Proliferation Animals MAP Kinase Signaling System Matrix Metalloproteinase 2 Antineoplastic Agents ADAM Proteins
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Exposure to fipronil elevates systolic blood pressure and disturbs related biomarkers in plasma of rats.

Environmental toxicology and pharmacology Dec 31, 2015
Recent reports show that fipronil affects non-target organisms, including environmental species populations and potentially humans. We aimed to examine if fipronil exposure affects the systolic blood pressure and related biomarkers. Thus, fipronil wa...
Insecticides Pyrazoles Biomarkers Animals Male Rats Nitric Oxide Blood Pressure Matrix Metalloproteinase 2
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Exploring shared pathogenic mechanisms and biomarkers in hepatic fibrosis and inflammatory bowel disease through bioinformatics and machine learning.

Frontiers in immunology Jan 1, 2025
BACKGROUND: The coexistence of hepatic fibrosis (HF) and inflammatory bowel disease (IBD) represents a significant clinical concern due to their poorly characterized shared pathogenic mechanisms. Current limitations in identifying common biomarkers f...
Computational Biology Liver Cirrhosis Matrix Metalloproteinase 2 Transcriptome Protein Interaction Maps Gene Regulatory Networks Humans Machine Learning Biomarkers Inflammatory Bowel Diseases Gene Expression Profiling
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Nanoscale Robots Exhibiting Quorum Sensing.

Artificial life Jan 1, 2019
Multi-agent systems demonstrate the ability to collectively perform complex tasks (e.g., construction, search, and locomotion) with greater speed, efficiency, or effectiveness than could a single agent alone. Direct and indirect coordination methods ...
DNA Matrix Metalloproteinase 2 Nanostructures Nanotechnology Robotics Quorum Sensing Platelet-Derived Growth Factor
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6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression.

Anais da Academia Brasileira de Ciencias Jan 1, 2017
6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice w...
Mice, Inbred C57BL Transforming Growth Factor beta Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Vascular Endothelial Growth Factor A Catechols Random Allocation Male Mice Insulin-Like Growth Factor I Plant Extracts Female Animals Hair Follicle Fatty Alcohols Enzyme Induction Fibroblast Growth Factor 7
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Effect of doxycycline on transforming growth factor-beta-1-induced matrix metalloproteinase 2 expression, migration, and collagen contraction in nasal polyp-derived fibroblasts.

American journal of rhinology & allergy Nov 1, 2016
PURPOSE: It is well known that doxycycline has antibacterial and anti-inflammatory effects. In this study, we aimed to investigate the effects of doxycycline on the transforming growth factor (TGF) beta 1-induced matrix metalloproteinase (MMP) 2 expr...
Collagen Gene Expression Regulation Doxycycline Smad2 Protein Young Adult Cell Differentiation Adult Transforming Growth Factor beta1 Humans Male Matrix Metalloproteinase 2 Cells, Cultured Signal Transduction Female Cell Movement Fibroblasts Nasal Polyps
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