Humoral and cell-mediated immune responses to COVID-19 vaccines up to 6 months post three-dose primary series in adults with inborn errors of immunity and their breakthrough infections.

Journal: Frontiers in immunology
PMID:

Abstract

PURPOSE: Many individuals with inborn errors of immunity (IEIs) have poor humoral immune (HI) vaccine responses. Only a few studies have examined specific cell-mediated immune (CMI) responses to coronavirus disease 2019 (COVID-19) vaccines in this population. Therefore, the purpose of this study was to examine HI and CMI responses up to 6 months post-COVID-19 vaccine dose 3 in adults with IEIs.

Authors

  • Dana Unninayar
    Inflammation and Chronic Disease Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
  • Emilia L Falcone
    Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
  • Hugo Chapdelaine
    Department of Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
  • Donald C Vinh
    Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.
  • Karina A Top
    IWK Health, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
  • Beata Derfalvi
    IWK Health, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
  • Thomas B Issekutz
    IWK Health, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.
  • Hélène Decaluwe
    Centre Hospitalier de l'Université (CHU) Ste Justine, Centre de Recherche, Montreal, QC, Canada.
  • Anne Pham-Huy
    Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
  • Julia Upton
    The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
  • Stephen D Betschel
    Clinical Immunology and Allergy, Unity Health Toronto, Toronto, ON, Canada.
  • Tamar Rubin
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
  • Sneha Suresh
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
  • Nicola A M Wright
    Alberta Children's Hospital, Calgary, AB, Canada.
  • Luis Murguía-Favela
    Alberta Children's Hospital, Calgary, AB, Canada.
  • Tatiana Kalashnikova
    Alberta Children's Hospital, Calgary, AB, Canada.
  • Lisa Barrett
    Department of Medicine, Dalhousie University, Halifax, NS, Canada.
  • Sharon Oldford
    Department of Medicine, Dalhousie University, Halifax, NS, Canada.
  • Marc-Andre Langlois
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
  • Corey Arnold
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
  • Manish Sadarangani
    Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
  • Tinghua Zhang
    Inflammation and Chronic Disease Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
  • Tim Ramsay
    Inflammation and Chronic Disease Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
  • Dina Yazji
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
  • Juthaporn Cowan
    Inflammation and Chronic Disease Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.