AIMC Topic: Antibodies, Viral
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Leveraging pre-vaccination antibody titres across multiple influenza H3N2 variants to forecast the post-vaccination response.
EBioMedicine
May 26, 2025
BACKGROUND: Despite decades of research on the influenza virus, we still lack a predictive understanding of how vaccination reshapes each person's antibody response, which impedes efforts to design better vaccines. Models using pre-vaccination antibo...
AI designed, mutation resistant broad neutralizing antibodies against multiple SARS-CoV-2 strains.
Scientific reports
May 3, 2025
In this study, we developed a digital twin for SARS-CoV-2 by integrating diverse data and metadata with multiple data types and processing strategies, including machine learning, natural language processing, protein structural modeling, and protein s...
Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2.
Nature biomedical engineering
Mar 5, 2025
Most antibodies for treating COVID-19 rely on binding the receptor-binding domain (RBD) of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). However, Omicron and its sub-lineages, as well as other heavily mutated variants, have rendered m...
Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies.
PLoS pathogens
Jan 23, 2025
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to persist, demonstrating the risks posed by emerging infectious diseases to national security, public health, and the economy. Development of new vaccines and antibodies for emer...
Humoral and cell-mediated immune responses to COVID-19 vaccines up to 6 months post three-dose primary series in adults with inborn errors of immunity and their breakthrough infections.
Frontiers in immunology
Jan 21, 2025
PURPOSE: Many individuals with inborn errors of immunity (IEIs) have poor humoral immune (HI) vaccine responses. Only a few studies have examined specific cell-mediated immune (CMI) responses to coronavirus disease 2019 (COVID-19) vaccines in this po...
Predicting the infecting dengue serotype from antibody titre data using machine learning.
PLoS computational biology
Dec 23, 2024
The development of a safe and efficacious vaccine that provides immunity against all four dengue virus serotypes is a priority, and a significant challenge for vaccine development has been defining and measuring serotype-specific outcomes and correla...
Using machine learning for personalized prediction of longitudinal coronavirus disease 2019 vaccine responses in transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Dec 4, 2024
The coronavirus disease 2019 pandemic has underscored the importance of vaccines, especially for immunocompromised populations like solid organ transplant recipients, who often have weaker immune responses. The purpose of this study was to compare de...
A deep learning approach predicting the activity of COVID-19 therapeutics and vaccines against emerging variants.
NPJ systems biology and applications
Nov 27, 2024
Understanding which viral variants evade neutralization is crucial for improving antibody-based treatments, especially with rapidly evolving viruses like SARS-CoV-2. Yet, conventional assays are labor intensive and cannot capture the full spectrum of...
Surface-Enhanced Raman Scattering Combined with Machine Learning for Rapid and Sensitive Detection of Anti-SARS-CoV-2 IgG.
Biosensors
Oct 29, 2024
This work reports an efficient method to detect SARS-CoV-2 antibodies in blood samples based on SERS combined with a machine learning tool. For this purpose, gold nanoparticles directly conjugated with spike protein were used in human blood samples t...
Development, study, and comparison of models of cross-immunity to the influenza virus using statistical methods and machine learning.
Voprosy virusologii
Sep 26, 2024
INTRODUCTION: The World Health Organization considers the values of antibody titers in the hemagglutination inhibition assay as one of the most important criteria for assessing successful vaccination. Mathematical modeling of cross-immunity allows fo...
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