The Effect of the Prethanol Extract of Trifolium pratense Leaves on Interleukin-1β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes.

Journal: Cells, tissues, organs
PMID: 30703768

Abstract

BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease, characterized by cartilage degradation and inflammation. The proinflammatory cytokine, interleukin (IL)-1β, plays a crucial role in the pathogenesis of OA by inducing the release of other catabolic factors that contribute to cartilage degradation. Trifolium pratense L. (red clover) has been used as a medicinal plant in many countries and as a source of nutraceuticals to alleviate the symptoms of menopause. Ob-jectives: In this study, we aimed to evaluate the anticatabolic effect of 40% prethanol extract of T. pratense (40% PeTP) on IL-1β-stimulated chondrocytes.

Authors

  • Seul Ah Lee
    Department of Oral Biochemistry, College of Dentistry, Chosun University, Gwangju, Republic of Korea.
  • Sung-Min Moon
    CStech Research Institute, Gwangju, Republic of Korea.
  • Seul Hee Han
    CStech Research Institute, Gwangju, Republic of Korea.
  • Jae-Sung Kim
    Oral Biology Research Institute, College of Dentistry, Chosun University, Gwangju, Republic of Korea.
  • Do Kyung Kim
    Oral Biology Research Institute, College of Dentistry, Chosun University, Gwangju, Republic of Korea.
  • Chun Sung Kim
    Department of Oral Biochemistry, College of Dentistry, Chosun University, Gwangju, Republic of Korea, cskim2@chosun.ac.kr.

Keywords

External Resources

Popular Topics
Recent Journals