8-Hydroxy-2'-deoxyguanosine as a Discriminatory Biomarker for Early Detection of Breast Cancer.

Journal: Clinical breast cancer
PMID: 30683611

Abstract

BACKGROUND: Breast cancer (BC) is one of the most prevalent and reported cancers among Saudi women. Detection of BC in the early invasive stage (stages I, II) has an advantage in treating patients over detection in the late invasive stage (stages III, IV). Tumor markers are used to aid in diagnosis, treatment monitoring, and recurrence detection of malignant tumors. 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a marker of nucleic damage owing to oxidative stress.

Authors

  • Essam Eldin Mohamed Nour Eldin
    Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
  • Mahmoud Zaki El-Readi
    Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt. Electronic address: mzreadi@uqu.edu.sa.
  • Mohamed Mahmoud Nour Eldein
    Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; Department of Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Albagir Ali Alfalki
    Department of Surgery, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
  • Mohammad Ahmad Althubiti
    Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
  • Hala Fawzy Mohamed Kamel
    Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; Department of Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
  • Safaa Yehia Eid
    Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
  • Hiba Saeed Al-Amodi
    Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
  • Ahmad A Mirza
    Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Keywords

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