A novel algorithm to improve specificity in ovarian cancer detection.

Journal: Cancer treatment and research communications
PMID: 30207285

Abstract

BACKGROUND: Measurement of autoantibodies (AAbs) to tumor associated antigens has been proposed to aid in the early detection of ovarian cancer with high specificity. Here we describe a multiplex approach to evaluate selected peptide epitopes of p53 protein, and propose a novel approach to increase specificity and potentially sensitivity for discrimination between healthy women and women with cancerous masses.

Authors

  • Audrey Arjomandi
    Clinical Diagnostics Group, Bio-Rad Laboratories, 4000 Alfred Nobel Drive, Hercules, CA 94547, USA. Electronic address: Audrey_Arjomandi@bio-rad.com.
  • Michelle L Delanoy
    Clinical Diagnostics Group, Bio-Rad Laboratories, 4000 Alfred Nobel Drive, Hercules, CA 94547, USA.
  • Roger P Walker
    Clinical Diagnostics Group, Bio-Rad Laboratories, 4000 Alfred Nobel Drive, Hercules, CA 94547, USA.
  • Steven R Binder
    Clinical Diagnostics Group, Bio-Rad Laboratories, 4000 Alfred Nobel Drive, Hercules, CA 94547, USA.

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