Cupuaçu extract reduces nitrosative stress and modulates inflammatory mediators in the kidneys of experimental diabetes.

Journal: Clinical nutrition (Edinburgh, Scotland)
PMID: 29336891

Abstract

BACKGROUND & AIMS: We have previously reported an increased nitrosative stress in the kidneys of diabetic animals, which was reduced by an antioxidant probiotic. The present study evaluated whether the extract of cupuaçu (EC), an antioxidant compound rich in polyphenols and theograndins, when administered at a dose that can be reasonably obtained through daily consumption, could delay the onset of diabetic complications in the kidney.

Authors

  • Giovana R Punaro
    Nephrology Division, Federal University of Sao Paulo, Sao Paulo, Brazil; Laboratory of Nitric Oxide and Oxidative Stress, Federal University of Sao Paulo, Sao Paulo, Brazil. Electronic address: giovana.punaro@gmail.com.
  • Deyse Y Lima
    Nephrology Division, Federal University of Sao Paulo, Sao Paulo, Brazil; Laboratory of Nitric Oxide and Oxidative Stress, Federal University of Sao Paulo, Sao Paulo, Brazil.
  • Adelson M Rodrigues
    Translational Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil; Laboratory of Nitric Oxide and Oxidative Stress, Federal University of Sao Paulo, Sao Paulo, Brazil.
  • Samuel Pugliero
    Laboratory of Nitric Oxide and Oxidative Stress, Federal University of Sao Paulo, Sao Paulo, Brazil.
  • Margaret G Mouro
    Nephrology Division, Federal University of Sao Paulo, Sao Paulo, Brazil; Laboratory of Nitric Oxide and Oxidative Stress, Federal University of Sao Paulo, Sao Paulo, Brazil.
  • Marcelo M Rogero
    Department of Nutrition, Public Health College, University of Sao Paulo, Sao Paulo, Brazil.
  • Elisa M S Higa
    Nephrology Division, Federal University of Sao Paulo, Sao Paulo, Brazil; Translational Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil; Laboratory of Nitric Oxide and Oxidative Stress, Federal University of Sao Paulo, Sao Paulo, Brazil.

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