Machine-learning and combined analysis of single-cell and bulk-RNA sequencing identified a DC gene signature to predict prognosis and immunotherapy response for patients with lung adenocarcinoma.

Journal: Journal of cancer research and clinical oncology
PMID: 37507593

Abstract

BACKGROUND: Innate immune effectors, dendritic cells (DCs), influence cancer prognosis and immunotherapy significantly. As such, dendritic cells are important in killing tumors and influencing tumor microenvironment, whereas their roles in lung adenocarcinoma (LUAD) are largely unknown.

Authors

  • Liangyu Zhang
    Fine Art and Design College, Quanzhou Normal University, Quanzhou, 362000, China.
  • Maohao Guan
    Department of Thoracic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
  • Xun Zhang
    Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China.
  • Fengqiang Yu
    Department of Thoracic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. martinyu@fjmu.edu.cn.
  • Fancai Lai
    Department of Thoracic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. laifancai@fjmu.edu.cn.

Keywords

External Resources

Popular Topics
Recent Journals