Whole-brain radiotherapy associated with structural changes resembling aging as determined by anatomic surface-based deep learning.

Journal: Neuro-oncology
Published Date: Jul 6, 2023

Abstract

BACKGROUND: Brain metastases are the most common intracranial tumors in adults and are associated with significant morbidity and mortality. Whole-brain radiotherapy (WBRT) is used frequently in patients for palliation, but can result in neurocognitive deficits. While dose-dependent injury to individual areas such as the hippocampus has been demonstrated, global structural shape changes after WBRT remain to be studied.

Authors

  • Nikhil Rammohan
    Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Alexander Ho
    Department of Radiation Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Pierre Besson
    Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States; Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago IL, United States.
  • Tim J Kruser
    SSM Health Dean Medical Group, Turville Bay Radiation Oncology Center, Madison, WI, USA.
  • S Kathleen Bandt
    Department of Neurological Surgery, Northwestern University, Feinberg School of Medicine, Chicago IL, United States. Electronic address: skbandt@gmail.com.

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