Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
PMID: 29288758

Abstract

Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine. Despite the existence of some works on the biological activities of this species, its chemical composition is still poorly known. The aim of this study was to extend the knowledge on the phytochemistry and biological properties of this species. Aqueous extracts from F. exasperata leaves and stem bark were analysed. Thirty-one phenolic compounds, comprising cinnamoyl derivatives, flavonoid-O-glycosides, flavonoid-mono-C-glycosides, flavonoid-di-C-glycosides and one furanocoumarin, were determined by HPLC-DAD-ESI/MS and UPLC-ESI-QTOF-MS, 26 of them being reported for the first time in this species. The profile of organic acids, characterized by HPLC-UV, was also reported for the first time. The best radical scavenging activity was observed for the aqueous extract from leaves (IC values of 222.5, 510.0 and 50.0 μg/mL against DPPH, NO and O, respectively). In addition, both aqueous extracts of the leaves and stem bark displayed a weak effect on α-amylase, and no cytotoxicity against gastric adenocarcinoma cell line, AGS. This study contributes to the valorisation of these vegetal materials, which may have application in functional foods and/or nutraceuticals.

Authors

  • Didier G Mouho
    Laboratoire de Chimie Bio-Organique et de Substances Naturelles (LCBONS/www.lablcbosn.com), UFR-SFA, Université Nangui Abrogoua, 02 B.P. 801, Abidjan 02, Côte d'Ivoire.
  • Andreia P Oliveira
    REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
  • Charles Guillaume Kodjo
    Laboratoire de Chimie Bio-Organique et de Substances Naturelles (LCBONS/www.lablcbosn.com), UFR-SFA, Université Nangui Abrogoua, 02 B.P. 801, Abidjan 02, Côte d'Ivoire.
  • Patrícia Valentão
    REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal.
  • Angel Gil-Izquierdo
    Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100, Campus University Espinardo, Murcia, Spain.
  • Paula B Andrade
    REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
  • Zana Adama Ouattara
    Laboratoire de Chimie Bio-Organique et de Substances Naturelles (LCBONS/www.lablcbosn.com), UFR-SFA, Université Nangui Abrogoua, 02 B.P. 801, Abidjan 02, Côte d'Ivoire.
  • Yves-Alain Bekro
    Laboratoire de Chimie Bio-Organique et de Substances Naturelles (LCBONS/www.lablcbosn.com), UFR-SFA, Université Nangui Abrogoua, 02 B.P. 801, Abidjan 02, Côte d'Ivoire.
  • Federico Ferreres
    Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100, Campus University Espinardo, Murcia, Spain. Electronic address: federico@cebas.csic.es.

Keywords

External Resources

Popular Topics
Recent Journals