A novel method for the rapid detection of post-translationally modified visinin-like protein 1 in rat models of brain injury.

Journal: Brain injury
PMID: 29283288

Abstract

BACKGROUND: Although elevated serum levels of visinin-like protein 1 (VILIP-1), a neuron-specific calcium sensor protein, are associated with ischaemic stroke, only a single study has evaluated VILIP-1 as a biomarker of traumatic brain injury (TBI). The current proof-of-concept study was designed to determine whether serum VILIP-1 levels increase post-injury in a well-characterized rat unilateral cortical contusion model.

Authors

  • Melissa A Bradley-Whitman
    a Sanders-Brown Center on Aging , University of Kentucky , Lexington , KY , USA.
  • Kelly N Roberts
    b Spinal Cord and Brain Injury Research Center , Lexington , KY , USA.
  • Erin L Abner
    c Sanders-Brown Center on Aging & Department of Epidemiology, College of Public Health , University of Kentucky , Lexington , KY , USA.
  • Stephen W Scheff
    d Sanders-Brown Center on Aging & Department of Anatomy and Neurobiology , University of Kentucky , Lexington , KY , USA.
  • Bert C Lynn
    e Sanders-Brown Center on Aging, University of Kentucky Mass Spectrometry, Facility, & Department of Chemistry , University of Kentucky , Lexington , KY , USA.
  • Mark A Lovell
    f Sanders-Brown Center on Aging & Department of Chemistry , University of Kentucky , Lexington , KY , USA.

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