R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis.

Journal: Journal of translational medicine
PMID: 29282084

Abstract

BACKGROUND: Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor) improves pulmonary function in a sheep model of septic shock caused by Pseudomonas aeruginosa and smoke inhalation.

Authors

  • Hiroshi Ito
  • Erik Malgerud
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Sven Asmussen
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Ernesto Lopez
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA.
  • Andrew L Salzman
    Radikal Therapeutics, Inc., West Tisbury, MA, USA.
  • Perenlei Enkhbaatar
    Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, USA. peenkhba@utmb.edu.

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