AIMC Topic: Nitric Oxide Donors

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R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis.

Journal of translational medicine Dec 28, 2017
BACKGROUND: Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor) improves pulmonary function ...
Female Animals Lung Hemodynamics Sepsis Blood Proteins Body Fluids Pseudomonas aeruginosa Sheep Respiratory Function Tests Superoxides Smoke Inhalation Injury Nitric Oxide Donors Pulmonary Gas Exchange
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Nitric oxide-releasing injectable hydrogels with high antibacterial activity through in situ formation of peroxynitrite.

Acta biomaterialia Dec 18, 2017
UNLABELLED: Nitric oxide (NO) is an endogenous molecule with many critical biological functions that depend on its concentration. At high levels, NO provides broad-spectrum antibacterial effects through both its pathogen inhibition and killing abilit...
Humans Anti-Bacterial Agents Animals Microbial Sensitivity Tests Time Factors Nitric Oxide Escherichia coli Staphylococcus aureus Fibroblasts Reactive Oxygen Species Cell Death Injections Hydrogels Sus scrofa Dermis Nitric Oxide Donors Peroxynitrous Acid
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