Aerosol delivery during spontaneous breathing with different types of nebulizers- in vitro/ex vivo models evaluation.

Journal: Pulmonary pharmacology & therapeutics
PMID: 29277689

Abstract

BACKGROUND: Nebulizers for spontaneous breathing have been evaluated through different study designs. There are limitations in simulated bench models related to patient and nebulizer factors. The aim of this study was to determine the correlation of inhaled drug mass between in vitro and ex vivo studies by testing aerosol deposition of various types of nebulizers.

Authors

  • Hui-Ling Lin
    Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Respiratory Therapy, Chang Gung University of Science and Technology, Chiayi, Taiwan. Electronic address: huilingrrt@gmail.com.
  • Tien-Pei Fang
    Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chiayi, Taiwan; Department of Respiratory Therapy, Chang Gung University of Science and Technology, Chiayi, Taiwan.
  • Hui-Sun Cho
    Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Respiratory Therapy, Yuan's General Hospital, Kaohsiung, Taiwan.
  • Gwo-Hwa Wan
    Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Respiratory Therapy, Chang Gung University of Science and Technology, Chiayi, Taiwan; Department of Neurosurgery, Chang Gung Memorial Hospital-Linko, Taoyuan, Taiwan.
  • Meng-Jer Hsieh
    Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medicine, Chang Gung Memorial Hospital, ChiYi, Taiwan.
  • James B Fink
    Aerogen Pharma Corp., San Mateo, CA, USA.

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