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Bronchodilator Agents

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Aerosol delivery during spontaneous breathing with different types of nebulizers- in vitro/ex vivo models evaluation.

Pulmonary pharmacology & therapeutics
BACKGROUND: Nebulizers for spontaneous breathing have been evaluated through different study designs. There are limitations in simulated bench models related to patient and nebulizer factors. The aim of this study was to determine the correlation of ...

Predictive machine learning algorithm for COPD exacerbations using a digital inhaler with integrated sensors.

BMJ open respiratory research
PURPOSE: By using data obtained with digital inhalers, machine learning models have the potential to detect early signs of deterioration and predict impending exacerbations of chronic obstructive pulmonary disease (COPD) for individual patients. This...

An ensemble learning method for asthma control level detection with leveraging medical knowledge-based classifier and supervised learning.

Journal of medical systems
Approximately 300 million people are afflicted with asthma around the world, with the estimated death rate of 250,000 cases, indicating the significance of this disease. If not treated, it can turn into a serious public health problem. The best metho...

Diagnostic value of spirometry vs impulse oscillometry: A comparative study in children with sickle cell disease.

Pediatric pulmonology
BACKGROUND: Spirometry is conventionally used to diagnose airway diseases in children with sickle cell disease (C-SCD). However, spirometry is difficult for younger children to perform, is effort dependent, and it provides limited information on resp...

Detecting asthma exacerbations using daily home monitoring and machine learning.

The Journal of asthma : official journal of the Association for the Care of Asthma
OBJECTIVE: Acute exacerbations contribute significantly to the morbidity of asthma. Recent studies have shown that early detection and treatment of asthma exacerbations leads to improved outcomes. We aimed to develop a machine learning algorithm to d...

In vitro and in vivo performance modelling and optimisation of different dry powder inhalers: A complementary study of neural networks, genetic algorithms and decision trees.

International journal of clinical practice
INTRODUCTION: Aerosol delivery from DPIs could be affected by different factors. This study aimed to evaluate and predict the effects of different factors on drug delivery from DPIs.

Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to approval.

Expert opinion on investigational drugs
INTRODUCTION: Therapeutic advances in drug therapy of chronic obstructive pulmonary disease (COPD) really effective in suppressing the pathological processes underlying the disease deterioration are still needed. Artificial Intelligence (AI) via Mach...

Curve-Modelling and Machine Learning for a Better COPD Diagnosis.

International journal of chronic obstructive pulmonary disease
BACKGROUND: Development of new tools in artificial intelligence has an outstanding performance in the recognition of multidimensional patterns, which is why they have proven to be useful in the diagnosis of Chronic Obstructive Pulmonary Disease (COPD...