In clinical practice for the diagnosis of pulmonary tuberculosis (PTB), bronchoscopy is typically performed under airway surface anaesthesia. The effectiveness of this anaesthesia is closely associated with the smoothness of bronchoscopy diagnosis, a...
Ciprofloxacin (CFX) is a potent antibiotic for respiratory infections, but its poor solubility and high crystallinity limit its effectiveness in dry powder inhaler (DPI) delivery. Although soluble forms such as CFX hydrochloride are available, their ...
International journal of pharmaceutics
Sep 28, 2025
Dry powder inhalers (DPIs) are widely used for pulmonary drug delivery, and their aerodynamic performance is highly dependent on particle surface morphology. This paper presents a machine learning-based framework to quantitatively predict DPI aerodyn...
The development of dry powder inhalers (DPIs) for pulmonary drug delivery is complex, requiring optimization of variable factors to ensure effective lung deposition. This study investigates the factors influencing the dispersibility of glycopyrronium...
International journal of pharmaceutics
Jul 24, 2025
This critical review provided a detailed strengths, weaknesses, opportunities, and threats (SWOT) analysis of nebulized liposomal formulations, focusing on the strengths and translational potential. The formulations have notable strengths, such as en...
International journal of pharmaceutics
Jul 23, 2025
Misuse and poor inhalation techniques remain persistent issues in pulmonary drug delivery via dry powder inhalation. While acoustic-based monitoring has been a feasible strategy, existing approaches often depend on smartphones for signal collection, ...
International journal of pharmaceutics
Jun 8, 2025
Co-spray drying technology represents an increasingly important approach in preparing dry powder inhalation (DPI) formulations. Compared to conventional spray drying, co-spray drying typically yields particles characterized by improved aerosol perfor...
BACKGROUND: In people with chronic obstructive pulmonary disease (COPD) on inhaled corticosteroid/long-acting β-agonist (ICS/LABA) therapy, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends stepping up to ICS/long-acting mu...
Pathophysiologic changes in lung diseases are often accompanied by changes in ventilation and gas exchange. Comprehensive evaluation of lung function cannot be obtained through chest X-ray and computed tomography. Proton-based lung MRI is particularl...
Expert opinion on investigational drugs
Jul 6, 2023
INTRODUCTION: Therapeutic advances in drug therapy of chronic obstructive pulmonary disease (COPD) really effective in suppressing the pathological processes underlying the disease deterioration are still needed. Artificial Intelligence (AI) via Mach...
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