Identification and validation of potential diagnostic signature and immune cell infiltration for HIRI based on cuproptosis-related genes through bioinformatics analysis and machine learning.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND AND AIMS: Cuproptosis has emerged as a significant contributor in the progression of various diseases. This study aimed to assess the potential impact of cuproptosis-related genes (CRGs) on the development of hepatic ischemia and reperfusion injury (HIRI).

Authors

  • Fang Xiao
    Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Guozhen Huang
    Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Guandou Yuan
    Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • Shuangjiang Li
    Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Yong Wang
    State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hunghom Kowloon Hong Kong P. R. China kwok-yin.wong@polyu.edu.hk.
  • Zhi Tan
    Graduate School, Woosuk University, Jeonju 514500, Republic of Korea.
  • Zhipeng Liu
    Institute of Advanced Materials (IAM) & Key Laboratory of Flexible Electronics (KLOFE), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, PR China.
  • Stephen Tomlinson
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States.
  • Songqing He
    Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • Guoqing Ouyang
    Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • Yonglian Zeng
    Division of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.