Effect of Long-Term Hormonal Therapy (vs Short-Term Hormonal Therapy): A Secondary Analysis of Intermediate-Risk Prostate Cancer Patients Treated on NRG Oncology RTOG 9202.

Journal: International journal of radiation oncology, biology, physics
PMID: 28126300

Abstract

PURPOSE: NRG Oncology RTOG 9202 was a randomized trial testing long-term adjuvant androgen deprivation (LTAD) versus initial androgen deprivation only (STAD) with external beam radiation therapy (RT) in mostly high-risk and some intermediate-risk prostate cancer patients. RTOG 9408 found an overall survival (OS) advantage in patients with cT1b-T2b disease and prostate-specific antigen (PSA) <20 ng/mL, with benefit observed mostly among intermediate-risk patients. It was still unknown whether intermediate-risk patients would experience an additional survival benefit with LTAD; thus, we performed a secondary analysis to explore whether LTAD had any incremental benefit beyond STAD among the intermediate-risk subset of RTOG 9202. The study endpoints were OS, disease-specific survival (DSS), and PSA failure (PSAF).

Authors

  • Amin J Mirhadi
    Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: amin.mirhadi@cshs.org.
  • Qiang Zhang
    Yunan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
  • Gerald E Hanks
    Fox Chase Cancer Center, Philadelphia, Pennsylvania.
  • Herbert Lepor
    NYU Medical Center, New York, New York.
  • David J Grignon
    Indiana University, Indianapolis, Indiana.
  • Christopher A Peters
    Northeast Radiation Oncology Center, Dunmore, Pennsylvania.
  • Seth A Rosenthal
    Sutter General Hospital, accruals for Radiological Associates of Sacramento, Sacramento, California.
  • Kenneth Zeitzer
    Albert Einstein Medical Center, Philadelphia, Pennsylvania.
  • John S Radwan
    London Regional Cancer Program, London, Ontario, Canada.
  • Colleen Lawton
    Medical College of Wisconsin, Milwaukee, Wisconsin.
  • Matthew B Parliament
    Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
  • Robert S Reznik
    Cedars-Sinai Medical Center, Los Angeles, California.
  • Howard M Sandler
    Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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