AIMC Topic: Androgen Antagonists

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A multicentre implementation trial of an Artificial Intelligence-driven biomarker to inform Shared decisions for androgen deprivation therapy in men undergoing prostate radiotherapy: the ASTuTE protocol.

BMC cancer Feb 13, 2025
BACKGROUND: Androgen deprivation therapy (ADT) improves outcomes in men undergoing definitive radiotherapy for prostate cancer but carries significant toxicities. Clinical parameters alone are insufficient to accurately identify patients who will der...
Humans Artificial Intelligence Australia Multicenter Studies as Topic Prostatic Neoplasms Androgen Antagonists Prognosis Biomarkers, Tumor Male
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Digital Pathology-Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer.

JCO precision oncology Jan 31, 2025
PURPOSE: The SPARTAN trial demonstrated that the addition of apalutamide to androgen deprivation therapy improves outcomes among patients with nonmetastatic castration-resistant prostate cancer (nmCRPC). We applied a previously reported digital histo...
Prostatic Neoplasms, Castration-Resistant Thiohydantoins Middle Aged Humans Treatment Outcome Artificial Intelligence Androgen Antagonists Aged Male
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An AI Predictive Model to Determine Who Benefits from ADT with Radiation: Working Smarter, Not Harder.

NEJM evidence Jul 25, 2023
Whether you are a surgical, medical, or radiation oncologist, the care goals remain the same, that is, achieving a durable treatment response. For patients with localized intermediate-risk prostate cancer undergoing radiation treatment, identifying t...
Male Humans Prostatic Neoplasms Androgen Antagonists Prognosis Risk Factors
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Artificial Intelligence Predictive Model for Hormone Therapy Use in Prostate Cancer.

NEJM evidence Jun 29, 2023
BACKGROUND: Androgen deprivation therapy (ADT) with radiotherapy can benefit patients with localized prostate cancer. However, ADT can negatively impact quality of life, and there remain no validated predictive models to guide its use. METHODS: We us...
Artificial Intelligence Male Humans Prostatic Neoplasms Prostate-Specific Antigen Androgen Antagonists Hormones
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Robot-assisted Laparoscopic Prostatectomy After SpaceOAR Placement.

Urology Apr 20, 2023
BACKGROUND: Patients with prostate cancer are offered a wide range of treatments from radiation therapy to chemotherapy to surgery. When giving radiation therapy, SpaceOAR hydrogel has been part of the standard treatment for the last decade to reduce...
Androgen Antagonists Hydrogels Prostatectomy Robotics Cicatrix Prostatic Neoplasms Laparoscopy Humans Male Middle Aged
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Assessment of oligometastasis status of prostate cancer following combined robot-assisted radical prostatectomy and androgen deprivation versus androgen deprivation therapy alone using PSA percentage decline rate.

Frontiers in endocrinology Feb 9, 2023
OBJECTIVE: To compare the tumor control in prostate cancer patients with oligo-metastasis following combined robot-assisted radical prostatectomy and androgen deprivation versus androgen deprivation therapy alone based on total prostate-specific anti...
Humans Retrospective Studies Male Prostate Androgen Antagonists Prostatectomy Androgens Robotics Prostatic Neoplasms Prostate-Specific Antigen
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The Effect of Salvage Radiation Therapy on Survival, Functional Outcomes, and Quality of Life in Men with Persistent Prostate-specific Antigen After Robot-Assisted Radical Prostatectomy: Which Patient Benefits More?

Practical radiation oncology Jul 14, 2022
PURPOSE: The aim of this study was to evaluate the effect of salvage radiation therapy (sRT) on survival, functional outcomes, and quality of life in men with persistent prostate-specific antigen (PSA >0.1 ng/mL) after a robot-assisted radical prosta...
Prostatectomy Androgen Antagonists Neoplasm Recurrence, Local Salvage Therapy Humans Retrospective Studies Male Quality of Life Robotics Prostatic Neoplasms Prostate-Specific Antigen
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BPA, BADGE and analogues: A new multi-analyte LC-ESI-MS/MS method for their determination and their in vitro (anti)estrogenic and (anti)androgenic properties.

Chemosphere Dec 28, 2018
Information on the occurrence and endocrine potencies of analogues of bisphenol A (BPA) and diglycidyl ester derivatives (BDGEs) of BPA and BPF is limited. Such information is, however, important as the current debate on BPA and the lowered BPA migra...
Androgen Antagonists Tandem Mass Spectrometry Esters Benzhydryl Compounds Europe Food Contamination Chromatography, Liquid Phenols Estrogen Antagonists
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Machine Learning on a Genome-wide Association Study to Predict Late Genitourinary Toxicity After Prostate Radiation Therapy.

International journal of radiation oncology, biology, physics Jan 31, 2018
PURPOSE: Late genitourinary (GU) toxicity after radiation therapy limits the quality of life of prostate cancer survivors; however, efforts to explain GU toxicity using patient and dose information have remained unsuccessful. We identified patients w...
Urination Symptom Assessment Urogenital System Nocturia Risk Lower Urinary Tract Symptoms Urinary Retention Humans Machine Learning Genome-Wide Association Study Area Under Curve Reproducibility of Results Polymorphism, Single Nucleotide Confidence Intervals Prostatic Neoplasms Regression Analysis Genotyping Techniques Male Androgen Antagonists Predictive Value of Tests Brachytherapy Quality of Life Urination Disorders
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Post prostatectomy outcomes of patients with high-risk prostate cancer treated with neoadjuvant androgen blockade.

Prostate cancer and prostatic diseases Dec 20, 2017
BACKGROUND: Patients with high-risk prostate cancer have an increased likelihood of experiencing a relapse following radical prostatectomy (RP). We previously conducted three neoadjuvant androgen-deprivation therapy (ADT) trials prior to RP in unfavo...
Androgen Antagonists Neoplasm Recurrence, Local Disease-Free Survival Prostatectomy Kallikreins Prostatic Neoplasms Neoplasm Staging Prostate-Specific Antigen Male Prostate Middle Aged Humans Follow-Up Studies Treatment Outcome Aged Multicenter Studies as Topic Neoadjuvant Therapy Randomized Controlled Trials as Topic
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