Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma.
Journal:
Frontiers in immunology
PMID:
39835132
Abstract
BACKGROUND: The Aryl Hydrocarbon Receptor (AhR) pathway significantly influences immune cell regulation, impacting the effectiveness of immunotherapy and patient outcomes in melanoma. However, the specific downstream targets and mechanisms by which AhR influences melanoma remain insufficiently understood.
Authors
Keywords
Animals
Basic Helix-Loop-Helix Transcription Factors
Biomarkers, Tumor
Computational Biology
Databases, Genetic
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Lymphocytes, Tumor-Infiltrating
Machine Learning
Melanoma
Mice
Prognosis
Receptors, Aryl Hydrocarbon
Skin Neoplasms
Transcriptome
Tumor Microenvironment