AIMC Topic: Receptors, Aryl Hydrocarbon

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Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma.

Frontiers in immunology Jan 6, 2025
BACKGROUND: The Aryl Hydrocarbon Receptor (AhR) pathway significantly influences immune cell regulation, impacting the effectiveness of immunotherapy and patient outcomes in melanoma. However, the specific downstream targets and mechanisms by which A...
Basic Helix-Loop-Helix Transcription Factors Receptors, Aryl Hydrocarbon Databases, Genetic Lymphocytes, Tumor-Infiltrating Animals Gene Expression Profiling Biomarkers, Tumor Melanoma Computational Biology Tumor Microenvironment Gene Expression Regulation, Neoplastic Skin Neoplasms Mice Transcriptome Prognosis Humans Machine Learning
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Investigating the Aryl Hydrocarbon Receptor Agonist/Antagonist Conformational Switch Using Well-Tempered Metadynamics Simulations.

Journal of chemical information and modeling Mar 8, 2024
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates biological signals to control various complicated cellular functions. It plays a crucial role in environmental sensing and xenobiotic metabolism. Dysregulati...
Humans Ligands Aryl Hydrocarbon Receptor Nuclear Translocator Receptors, Aryl Hydrocarbon Artificial Intelligence
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Prediction Model of Aryl Hydrocarbon Receptor Activation by a Novel QSAR Approach, DeepSnap-Deep Learning.

Molecules (Basel, Switzerland) Mar 13, 2020
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that senses environmental exogenous and endogenous ligands or xenobiotic chemicals. In particular, exposure of the liver to environmental metabolism-disrupting chemicals c...
Animals Cell Line, Tumor Deep Learning Models, Molecular Principal Component Analysis Quantitative Structure-Activity Relationship Rats Receptors, Aryl Hydrocarbon ROC Curve
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Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants.

Toxicological sciences : an official journal of the Society of Toxicology Nov 28, 2023
The aryl hydrocarbon receptor (AhR) is an inducible transcription factor whose ligands include the potent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand-activated AhR binds to DNA at dioxin response elements (DREs) conta...
Organ Specificity Genome, Human Machine Learning Humans Receptors, Aryl Hydrocarbon Basic Helix-Loop-Helix Transcription Factors
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Profiling prediction of nuclear receptor modulators with multi-task deep learning methods: toward the virtual screening.

Briefings in bioinformatics Sep 20, 2022
Nuclear receptors (NRs) are ligand-activated transcription factors, which constitute one of the most important targets for drug discovery. Current computational strategies mainly focus on a single target, and the transfer of learned knowledge among N...
Proto-Oncogene Proteins c-met B-Cell Activation Factor Receptor Receptors, Artificial Histamine H2 Antagonists Neurokinin-1 Receptor Antagonists Cytokine Receptor gp130 Calcitonin Receptor-Like Protein Deep Learning Ligands Receptor, Metabotropic Glutamate 5 Receptors, Cytoplasmic and Nuclear Receptors, Aryl Hydrocarbon Receptors, Calcitriol Receptors, Muscarinic Receptors, Gastrointestinal Hormone Receptor-Like Protein Tyrosine Phosphatases, Class 2 Receptors, Polymeric Immunoglobulin
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