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Receptors, Aryl Hydrocarbon

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Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma.

Frontiers in immunology 39835132
BACKGROUND: The Aryl Hydrocarbon Receptor (AhR) pathway significantly influences immune cell regulation, impacting the effectiveness of immunotherapy and patient outcomes in melanoma. However, the specific downstream targets and mechanisms by which A...
Animals Basic Helix-Loop-Helix Transcription Factors Biomarkers, Tumor Computational Biology Databases, Genetic Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Lymphocytes, Tumor-Infiltrating Machine Learning Melanoma Mice Prognosis Receptors, Aryl Hydrocarbon Skin Neoplasms Transcriptome Tumor Microenvironment
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Prediction Model of Aryl Hydrocarbon Receptor Activation by a Novel QSAR Approach, DeepSnap-Deep Learning.

Molecules (Basel, Switzerland) 32183141
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that senses environmental exogenous and endogenous ligands or xenobiotic chemicals. In particular, exposure of the liver to environmental metabolism-disrupting chemicals c...
Animals Cell Line, Tumor Deep Learning Models, Molecular Principal Component Analysis Quantitative Structure-Activity Relationship Rats Receptors, Aryl Hydrocarbon ROC Curve
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Profiling prediction of nuclear receptor modulators with multi-task deep learning methods: toward the virtual screening.

Briefings in bioinformatics 35998896
Nuclear receptors (NRs) are ligand-activated transcription factors, which constitute one of the most important targets for drug discovery. Current computational strategies mainly focus on a single target, and the transfer of learned knowledge among N...
B-Cell Activation Factor Receptor Calcitonin Receptor-Like Protein Cytokine Receptor gp130 Deep Learning Histamine H2 Antagonists Ligands Neurokinin-1 Receptor Antagonists Proto-Oncogene Proteins c-met Receptor-Like Protein Tyrosine Phosphatases, Class 2 Receptor, Metabotropic Glutamate 5 Receptors, Artificial Receptors, Aryl Hydrocarbon Receptors, Calcitriol Receptors, Cytoplasmic and Nuclear Receptors, Gastrointestinal Hormone Receptors, Muscarinic Receptors, Polymeric Immunoglobulin
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Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants.

Toxicological sciences : an official journal of the Society of Toxicology 37707797
The aryl hydrocarbon receptor (AhR) is an inducible transcription factor whose ligands include the potent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand-activated AhR binds to DNA at dioxin response elements (DREs) conta...
Basic Helix-Loop-Helix Transcription Factors Genome, Human Humans Machine Learning Organ Specificity Receptors, Aryl Hydrocarbon
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Investigating the Aryl Hydrocarbon Receptor Agonist/Antagonist Conformational Switch Using Well-Tempered Metadynamics Simulations.

Journal of chemical information and modeling 38457778
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates biological signals to control various complicated cellular functions. It plays a crucial role in environmental sensing and xenobiotic metabolism. Dysregulati...
Artificial Intelligence Aryl Hydrocarbon Receptor Nuclear Translocator Humans Ligands Receptors, Aryl Hydrocarbon
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