AIMC Topic: Receptors, Aryl Hydrocarbon

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Integrating machine learning and molecular dynamics simulation to decipher the molecular network of dioxin-associated liposarcoma.

Scientific reports Nov 17, 2025
Dioxin-like pollutants, especially 2,3,7,8-Tetrachlorodibenzo-p-dioxin, are recognized human carcinogens. Retrospective studies suggest a link between dioxins and soft tissue sarcomas, including liposarcoma, but mechanisms remain unclear. This study ...
Humans Machine Learning Molecular Docking Simulation Liposarcoma Dioxins Polychlorinated Dibenzodioxins Receptors, Aryl Hydrocarbon Molecular Dynamics Simulation
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Identification and validation of aryl hydrocarbon receptor-associated hub genes in ulcerative colitis via integrated bioinformatics analysis.

Human genomics Oct 15, 2025
OBJECTIVE: Ulcerative colitis (UC), a chronic inflammatory bowel disease, continues to pose substantial challenges in both diagnosis and treatment. The aryl hydrocarbon receptor (AhR) plays a pivotal role in intestinal immune regulation; however, its...
Humans Animals Indoleamine-Pyrrole 2,3,-Dioxygenase Dextran Sulfate Gene Regulatory Networks Mice Computational Biology Gene Expression Profiling Protein Interaction Maps Interleukin-1beta Receptors, Aryl Hydrocarbon Gene Ontology Disease Models, Animal Colitis, Ulcerative
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Event-Driven Taxonomy (EDT) Screening: Leveraging Effect-Based Spectral Libraries to Accelerate Semiquantitative Nontarget Analysis of AhR Agonists in Sediment in the Era of Big Data.

Environmental science & technology Jul 8, 2025
Sediments contain complex chemical mixtures. While effect-directed analysis (EDA) combined with nontarget screening (NTS) is promising, its large-scale application has been limited by time-consuming workflows. Here, we developed an event-driven taxon...
Big Data Geologic Sediments Receptors, Aryl Hydrocarbon Water Pollutants, Chemical
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Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma.

Frontiers in immunology Jan 6, 2025
BACKGROUND: The Aryl Hydrocarbon Receptor (AhR) pathway significantly influences immune cell regulation, impacting the effectiveness of immunotherapy and patient outcomes in melanoma. However, the specific downstream targets and mechanisms by which A...
Gene Expression Regulation, Neoplastic Lymphocytes, Tumor-Infiltrating Receptors, Aryl Hydrocarbon Mice Computational Biology Databases, Genetic Basic Helix-Loop-Helix Transcription Factors Tumor Microenvironment Biomarkers, Tumor Gene Expression Profiling Transcriptome Animals Prognosis Melanoma Humans Skin Neoplasms Machine Learning
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Investigating the Aryl Hydrocarbon Receptor Agonist/Antagonist Conformational Switch Using Well-Tempered Metadynamics Simulations.

Journal of chemical information and modeling Mar 8, 2024
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates biological signals to control various complicated cellular functions. It plays a crucial role in environmental sensing and xenobiotic metabolism. Dysregulati...
Ligands Aryl Hydrocarbon Receptor Nuclear Translocator Artificial Intelligence Receptors, Aryl Hydrocarbon Humans
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Prediction Model of Aryl Hydrocarbon Receptor Activation by a Novel QSAR Approach, DeepSnap-Deep Learning.

Molecules (Basel, Switzerland) Mar 13, 2020
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that senses environmental exogenous and endogenous ligands or xenobiotic chemicals. In particular, exposure of the liver to environmental metabolism-disrupting chemicals c...
Quantitative Structure-Activity Relationship Receptors, Aryl Hydrocarbon Principal Component Analysis Models, Molecular ROC Curve Animals Rats Deep Learning Cell Line, Tumor
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Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants.

Toxicological sciences : an official journal of the Society of Toxicology Nov 28, 2023
The aryl hydrocarbon receptor (AhR) is an inducible transcription factor whose ligands include the potent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ligand-activated AhR binds to DNA at dioxin response elements (DREs) conta...
Receptors, Aryl Hydrocarbon Basic Helix-Loop-Helix Transcription Factors Organ Specificity Genome, Human Humans Machine Learning
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Profiling prediction of nuclear receptor modulators with multi-task deep learning methods: toward the virtual screening.

Briefings in bioinformatics Sep 20, 2022
Nuclear receptors (NRs) are ligand-activated transcription factors, which constitute one of the most important targets for drug discovery. Current computational strategies mainly focus on a single target, and the transfer of learned knowledge among N...
Receptors, Polymeric Immunoglobulin Receptor-Like Protein Tyrosine Phosphatases, Class 2 Receptors, Gastrointestinal Hormone Deep Learning Receptors, Aryl Hydrocarbon Receptors, Muscarinic Receptors, Calcitriol B-Cell Activation Factor Receptor Calcitonin Receptor-Like Protein Histamine H2 Antagonists Neurokinin-1 Receptor Antagonists Cytokine Receptor gp130 Receptor, Metabotropic Glutamate 5 Receptors, Artificial Proto-Oncogene Proteins c-met Ligands Receptors, Cytoplasmic and Nuclear
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