Unraveling the genetic and molecular landscape of sepsis and acute kidney injury: A comprehensive GWAS and machine learning approach.

Journal: International immunopharmacology
PMID:

Abstract

OBJECTIVES: This study aimed to explore the underlying mechanisms of sepsis and acute kidney injury (AKI), including sepsis-associated AKI (SA-AKI), a frequent complication in critically ill sepsis patients.

Authors

  • Sha Yang
    Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.
  • Jing Guo
    College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, Shaanxi, China.
  • Yunbiao Xiong
    Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China.
  • Guoqiang Han
  • Tao Luo
  • Shuo Peng
    Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China.
  • Jian Liu
    Department of Rheumatology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
  • Tieyi Hu
    Department of Neurology, the Affiliated Dazu Hospital of Chongqing Medical University , China.
  • Yan Zha
    Key Laboratory of Agricultural Remote Sensing (AGRIRS), Ministry of Agriculture and Rural Affairs/Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, China.
  • Xin Lin
    Department of Clinical Nutrition, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
  • Ying Tan
  • Jiqin Zhang
    Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, China. Electronic address: zhangjiqin@gz5055.com.