AI Medical Compendium Journal:
Microbial cell factories

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Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights.

Microbial cell factories
BACKGROUND: The rising danger of antibiotic resistance and the increasing burden of cancer worldwide have highlighted the necessity for a constant supply of new antimicrobial drugs and anticancer therapies. Endophytic fungi, recognized as a rich supp...

Improving the enzymatic activity and stability of N-carbamoyl hydrolase using deep learning approach.

Microbial cell factories
BACKGROUND: Optically active D-amino acids are widely used as intermediates in the synthesis of antibiotics, insecticides, and peptide hormones. Currently, the two-enzyme cascade reaction is the most efficient way to produce D-amino acids using enzym...

Construction of an enzyme-constrained metabolic network model for Myceliophthora thermophila using machine learning-based k data.

Microbial cell factories
BACKGROUND: Genome-scale metabolic models (GEMs) serve as effective tools for understanding cellular phenotypes and predicting engineering targets in the development of industrial strain. Enzyme-constrained genome-scale metabolic models (ecGEMs) have...