Journal of X-ray science and technology
Jan 1, 2019
BACKGROUND: Hip fracture is considered one of the salient disability factors across the global population. People with hip fractures are prone to become permanently disabled or die from complications. Although currently the premier determiner, bone m...
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jan 1, 2019
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2019
The drug discovery process is conventionally regarded as resource intensive and complex. Therefore, research effort has been put into a process called drug repositioning with the use of computational methods. Similarity-based methods are common in pr...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2019
Drug-target networks have an important role in pharmaceutical innovation, drug lead discovery, and recent drug repositioning tasks. Many different in silico approaches for the identification of new drug-target interactions have been proposed, many of...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2019
In this chapter, a new method to evaluate the reliability of predicting new uses of existing drugs was proposed. The prediction was performed with a support vector machine (SVM) using various data. Because the reliability of prediction could not be e...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2019
We present the baseline regularization model for computational drug repurposing using electronic health records (EHRs). In EHRs, drug prescriptions of various drugs are recorded throughout time for various patients. In the same time, numeric physical...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2019
Therapeutic effects of drugs are mediated via interactions between them and their intended targets. As such, prediction of drug-target interactions is of great importance. Drug-target interaction prediction is especially relevant in the case of drug ...
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