AIMC Topic: Aminoquinolines

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Activity prediction of aminoquinoline drugs based on deep learning.

Biotechnology and applied biochemistry Oct 11, 2020
The results of the traditional prediction method for the activity of aminoquinoline drugs are inaccurate, so the prediction method for the activity of aminoquinoline drugs based on the deep learning is designed. The molecular holographic distance vec...
Deep Learning Structure-Activity Relationship Molecular Structure Pharmaceutical Preparations Aminoquinolines
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Spatial discovery of pyrotinib overcoming HER2-positive breast cancer resistance by breaking fibroblast-induced immune barriers.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy Sep 1, 2025
BACKGROUND: The TCbHP regimen, consisting of combining docetaxel (T), carboplatin (Cb), trastuzumab (H), and pertuzumab (P), is the preferred neoadjuvant treatment for locally advanced human epidermal growth factor 2 (HER2)-positive breast cancer. Ho...
Humans Female Breast Neoplasms Tumor Microenvironment Cell Line, Tumor B7-H1 Antigen Antineoplastic Combined Chemotherapy Protocols Neoadjuvant Therapy Antibodies, Monoclonal, Humanized Fibroblasts Docetaxel Drug Resistance, Neoplasm Coculture Techniques Receptor, ErbB-2 Trastuzumab Acrylamides T-Lymphocytes, Cytotoxic Aminoquinolines
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