AIMC Topic: T-Lymphocytes, Cytotoxic

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Integrated structural proteomics and machine learning-guided mapping of a highly protective precision vaccine against mycoplasma pulmonis.

International immunopharmacology Aug 16, 2024
Mycoplasma pulmonis (M. pulmonis) is an emerging respiratory infection commonly linked to prostate cancer, and it is classified under the group of mycoplasmas. Improved management of mycoplasma infections is essential due to the frequent ineffectiven...
Machine Learning Animals Epitopes, T-Lymphocyte Molecular Docking Simulation Humans Epitope Mapping T-Lymphocytes, Cytotoxic Mycoplasma Infections Antigens, Bacterial Epitopes, B-Lymphocyte Bacterial Vaccines Mice Proteomics Bacterial Proteins
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Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning.

Science (New York, N.Y.) Dec 8, 2022
Chimeric antigen receptor (CAR) costimulatory domains derived from native immune receptors steer the phenotypic output of therapeutic T cells. We constructed a library of CARs containing ~2300 synthetic costimulatory domains, built from combinations ...
Receptors, Chimeric Antigen Peptide Library Signal Transduction Humans Machine Learning Phenotype Protein Domains T-Lymphocytes, Cytotoxic
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An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study.

Scientific reports Feb 5, 2021
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical the...
Immunogenicity, Vaccine T-Lymphocytes, Helper-Inducer Protein Conformation T-Lymphocytes, Cytotoxic Codon Usage Epitopes, B-Lymphocyte Vaccines, Subunit Molecular Dynamics Simulation Allergens Solubility Models, Molecular Mutation RNA, Viral Epitopes, T-Lymphocyte Spike Glycoprotein, Coronavirus Humans Molecular Docking Simulation Deep Learning Computational Biology COVID-19 COVID-19 Vaccines Drug Design SARS-CoV-2
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Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic Epitopes.

Cancer immunology research Sep 12, 2019
Current tumor neoantigen calling algorithms primarily rely on epitope/major histocompatibility complex (MHC) binding affinity predictions to rank and select for potential epitope targets. These algorithms do not predict for epitope immunogenicity usi...
Mice Computational Biology Cancer Vaccines Mice, Inbred C57BL Peptide Fragments Antigens, Neoplasm Mice, Inbred BALB C Male Histocompatibility Antigens Class I Algorithms Humans Neoplasms Histocompatibility Antigens Class II Female Epitopes, T-Lymphocyte Machine Learning T-Lymphocytes, Cytotoxic Animals
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and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Protein Stability Expert Systems Oligopeptides Computational Biology Peptide Fragments Melanoma Cancer Vaccines Epitopes Reproducibility of Results Protein Refolding Humans Antigens, Neoplasm HLA-A2 Antigen Animals Neoplasm Proteins T-Lymphocytes, Cytotoxic Immunogenicity, Vaccine Vaccines, Synthetic Artificial Intelligence Mice, Knockout Mice, Transgenic Membrane Proteins Cells, Cultured Models, Immunological
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Spatial discovery of pyrotinib overcoming HER2-positive breast cancer resistance by breaking fibroblast-induced immune barriers.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy Sep 1, 2025
BACKGROUND: The TCbHP regimen, consisting of combining docetaxel (T), carboplatin (Cb), trastuzumab (H), and pertuzumab (P), is the preferred neoadjuvant treatment for locally advanced human epidermal growth factor 2 (HER2)-positive breast cancer. Ho...
Neoadjuvant Therapy Antibodies, Monoclonal, Humanized Fibroblasts Docetaxel Cell Line, Tumor B7-H1 Antigen Antineoplastic Combined Chemotherapy Protocols Drug Resistance, Neoplasm Breast Neoplasms Trastuzumab Humans T-Lymphocytes, Cytotoxic Coculture Techniques Acrylamides Tumor Microenvironment Female Receptor, ErbB-2 Aminoquinolines
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