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T-Lymphocytes, Cytotoxic

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and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry 28536262
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Animals Antigens, Neoplasm Artificial Intelligence Cancer Vaccines Cells, Cultured Computational Biology Epitopes Expert Systems HLA-A2 Antigen Humans Immunogenicity, Vaccine Melanoma Membrane Proteins Mice, Knockout Mice, Transgenic Models, Immunological Neoplasm Proteins Oligopeptides Peptide Fragments Protein Refolding Protein Stability Reproducibility of Results T-Lymphocytes, Cytotoxic Vaccines, Synthetic
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Machine-Learning Prediction of Tumor Antigen Immunogenicity in the Selection of Therapeutic Epitopes.

Cancer immunology research 31515258
Current tumor neoantigen calling algorithms primarily rely on epitope/major histocompatibility complex (MHC) binding affinity predictions to rank and select for potential epitope targets. These algorithms do not predict for epitope immunogenicity usi...
Algorithms Animals Antigens, Neoplasm Cancer Vaccines Computational Biology Epitopes, T-Lymphocyte Female Histocompatibility Antigens Class I Histocompatibility Antigens Class II Humans Machine Learning Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasms Peptide Fragments T-Lymphocytes, Cytotoxic
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An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study.

Scientific reports 33547334
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical the...
Allergens Codon Usage Computational Biology COVID-19 COVID-19 Vaccines Deep Learning Drug Design Epitopes, B-Lymphocyte Epitopes, T-Lymphocyte Humans Immunogenicity, Vaccine Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Mutation Protein Conformation RNA, Viral SARS-CoV-2 Solubility Spike Glycoprotein, Coronavirus T-Lymphocytes, Cytotoxic T-Lymphocytes, Helper-Inducer Vaccines, Subunit
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Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning.

Science (New York, N.Y.) 36480602
Chimeric antigen receptor (CAR) costimulatory domains derived from native immune receptors steer the phenotypic output of therapeutic T cells. We constructed a library of CARs containing ~2300 synthetic costimulatory domains, built from combinations ...
Humans Machine Learning Peptide Library Phenotype Protein Domains Receptors, Chimeric Antigen Signal Transduction T-Lymphocytes, Cytotoxic
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Integrated structural proteomics and machine learning-guided mapping of a highly protective precision vaccine against mycoplasma pulmonis.

International immunopharmacology 39153303
Mycoplasma pulmonis (M. pulmonis) is an emerging respiratory infection commonly linked to prostate cancer, and it is classified under the group of mycoplasmas. Improved management of mycoplasma infections is essential due to the frequent ineffectiven...
Animals Antigens, Bacterial Bacterial Proteins Bacterial Vaccines Epitope Mapping Epitopes, B-Lymphocyte Epitopes, T-Lymphocyte Humans Machine Learning Mice Molecular Docking Simulation Mycoplasma Infections Proteomics T-Lymphocytes, Cytotoxic
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