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Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.

Journal of colloid and interface science 28068545
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Anhydrides Animals Anti-Inflammatory Agents, Non-Steroidal Cell Line Cell Survival Drug Carriers Drug Liberation Fumarates HeLa Cells Humans Hydrogen-Ion Concentration Hydrolysis Hydrophobic and Hydrophilic Interactions Ibuprofen Micelles Nanoparticles Polyethylene Glycols Polypropylenes Prodrugs Rabbits Solubility Surface Properties
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