AIMC Topic: Micelles
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POxload: Machine Learning Estimates Drug Loadings of Polymeric Micelles.
Molecular pharmaceutics
May 28, 2024
Block copolymers, composed of poly(2-oxazoline)s and poly(2-oxazine)s, can serve as drug delivery systems; they form micelles that carry poorly water-soluble drugs. Many recent studies have investigated the effects of structural changes of the polyme...
Prediction of critical micelle concentration for per- and polyfluoroalkyl substances.
SAR and QSAR in environmental research
Apr 9, 2024
In this study, we focus on the development of Quantitative Structure-Property Relationship (QSPR) models to predict the critical micelle concentration (CMC) for per- and polyfluoroalkyl substances (PFASs). Experimental CMC values for both fluorinated...
Formulation and optimization of silymarin-encapsulated binary micelles for enhanced amyloid disaggregation activity.
Drug development and industrial pharmacy
Apr 9, 2022
Silymarin (SLY) is a natural hydrophobic polyphenol that possesses antioxidant and amyloid fibril (Aβ) inhibition activity, but its activity is hindered due to low aqueous solubility. In this study, SLY is encapsulated in binary micelle (SLY-BM) that...
Lignin-Incorporated Nanogel Serving As an Antioxidant Biomaterial for Wound Healing.
ACS applied bio materials
Oct 1, 2020
Oxidative phosphorylation is an important biological process in the body to produce energy, during which oxygen free radicals are generated as byproduct. Excessive oxygen free radicals cause cell death and reduce the rate of tissue regeneration and h...
Multi-Responsive Bottlebrush-Like Unimolecules Self-Assembled Nano-Riceball for Synergistic Sono-Chemotherapy.
Small methods
Sep 2, 2020
Improved drug loading content, bioavailability, and controlled release in targeted tissue have been major bottlenecks in the design of precision nanomedicine. Herein, a tumor-specific and multiple-stimuli responsive nano-riceball is proposed and vali...
Micelle-dominated distribution strategy for non-matrix matched calibration without an internal standard: "Extract-and-shoot" approach for analyzing hydrophilic targets in blood and cell samples.
Analytica chimica acta
Dec 17, 2019
The analysis of trace hydrophilic targets in complex aqueous-rich matrices is considerably challenging, generally requiring matrix-matched calibration, internal standard, or time-and-labor-intensive sample preparation. To address this analytical bott...
Accurate intracellular and in vivo temperature sensing based on CuInS/ZnS QD micelles.
Journal of materials chemistry. B
Apr 1, 2019
Accurate and sensitive temperature sensing is of great importance for studying biological activities in cells and tissues. Due to the complexity of the microenvironments, most of the existing thermometry systems cannot meet the needs of accurate intr...
Hypoxia-responsive micelles self-assembled from amphiphilic block copolymers for the controlled release of anticancer drugs.
Journal of materials chemistry. B
Dec 12, 2018
Amphiphilic block copolymers poly(ethylene glycol)-block-poly(methacrylic acid-co-2-nitroimidazole methacrylate) (PEG-b-P(MAA-co-NIMA)) were synthesized by the combination of atom transfer radical polymerization (ATRP), hydrolysis and EDC reactions. ...
Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100: Characterization, solubility, and bioavailability study.
Colloids and surfaces. B, Biointerfaces
Dec 16, 2017
Toltrazuril (Tol) is a broad-spectrum anticoccidiosis drug that is widely used in the prevention and treatment of coccidiosis infection in poultry and mammals. However, the drug has poor aqueous solubility (25 °C, 0.41 μg/mL), and its dose escalation...
Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.
Journal of colloid and interface science
Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Humans
Animals
Nanoparticles
Anti-Inflammatory Agents, Non-Steroidal
Rabbits
Hydrogen-Ion Concentration
Polyethylene Glycols
Cell Line
Cell Survival
Drug Carriers
Polypropylenes
Surface Properties
Ibuprofen
Anhydrides
Fumarates
Micelles
Prodrugs
HeLa Cells
Hydrophobic and Hydrophilic Interactions
Hydrolysis
Solubility
Drug Liberation
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