AIMC Topic: Antibodies, Monoclonal
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Humanization of antibodies using a machine learning approach on large-scale repertoire data.
Bioinformatics (Oxford, England)
Nov 18, 2021
MOTIVATION: Monoclonal antibody (mAb) therapeutics are often produced from non-human sources (typically murine), and can therefore generate immunogenic responses in humans. Humanization procedures aim to produce antibody therapeutics that do not elic...
Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters.
mAbs
Jan 1, 2021
High viscosity presents a challenge for manufacturing and drug delivery of therapeutic antibodies. The viscosity is determined by protein-protein interactions among many antibodies. Molecular simulation is a promising method to study protein-protein ...
Dosing interval and diagnosis predict infliximab levels in patients with inflammatory bowel disease on maintenance treatment.
Acta gastro-enterologica Belgica
Jan 1, 2018
OBJECTIVE: The aim of the study was to identify factors influencing infliximab (IFX) trough levels (TL) in patients with inflammatory bowel disease (IBD).
Efficacy of eculizumab in an adult patient with HIV-associated hemolytic uremic syndrome: A case report.
Medicine
Dec 1, 2017
INTRODUCTION: Hemolytic uremic syndrome (HUS) in Human Immunodeficiency Virus (HIV)-positive patients has become a rare cause of kidney injury since the era of highly active antiretroviral therapy (HAART). Plasma exchange and antiretroviral therapy w...
Follow-Up Studies
Antibodies, Monoclonal
Antiretroviral Therapy, Highly Active
Acute Kidney Injury
Immunohistochemistry
Plasma Exchange
Biopsy, Needle
Treatment Outcome
Female
Humans
Kidney Function Tests
Middle Aged
Hemolytic-Uremic Syndrome
Antibodies, Monoclonal, Humanized
Risk Assessment
Renal Dialysis
HIV Infections
Study on the Simultaneously Quantitative Detection for β-Lactoglobulin and Lactoferrin of Cow Milk by Using Protein Chip Technique.
Biomedical and environmental sciences : BES
Dec 1, 2017
OBJECTIVE: To research a protein chip method which can simultaneously quantitative detect β-Lactoglobulin (β-L) and Lactoferrin (Lf) at one time.
Prokaryotic Expression of Hepatitis C Virus-NS3 Protein and Preparation of a Monoclonal Antibody.
Monoclonal antibodies in immunodiagnosis and immunotherapy
Dec 1, 2017
Hepatitis C virus (HCV) is a significant health threat that has been extensively investigated worldwide. Improving the sensitivity and specificity of laboratory tests for screening and early diagnosis of HCV in a relevant population is an effective m...
Prediction of delayed retention of antibodies in hydrophobic interaction chromatography from sequence using machine learning.
Bioinformatics (Oxford, England)
Dec 1, 2017
MOTIVATION: The hydrophobicity of a monoclonal antibody is an important biophysical property relevant for its developability into a therapeutic. In addition to characterizing heterogeneity, Hydrophobic Interaction Chromatography (HIC) is an assay tha...
[Preparation of monoclonal antibody against cystatin C and establishment of its immunoassay system].
Wei sheng yan jiu = Journal of hygiene research
Jul 1, 2017
OBJECTIVE: To prepare human cystatin C( CysC) recombinant protein and produce monoclonal antibodies with high affinity and specificity. Develop a competitive ELISA detection system to detect of CysC in human serum.
[Development, identification and application of 33 monoclonal antibodies against cardiac troponin T].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Dec 25, 2016
The aim of this study is to prepare and characterize cardiac troponin T (cTnT) monoclonal antibodies (mAb), and further develop a chemiluminescence quantitative detection assay for cTnT. BALB/c mice were immunized with recombinant cTnT antigen, and s...
[Fluoroimmunoassay and Magnetic Lateral Flow Immunoassay for the Detection of Ractopamine].
Guang pu xue yu guang pu fen xi = Guang pu
Nov 1, 2015
A fluoroimmunoassay based on quantum dots (QDs) and a lateral flow immunoassay system based on the magnetic beads (MB) were constructed to detect ractopamine (RAG) in urine samples. The monoclonal antibody (Ab1) against RAC was conjugated with QDs or...
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