AIMC Topic: Chromatography, Ion Exchange

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Accelerating mechanistic model calibration in protein chromatography using artificial neural networks.

Journal of chromatography. A Apr 11, 2025
In the manufacturing of therapeutic monoclonal antibodies (mAbs), mechanistic models can aid the evaluation and selection of suitable chromatography operating conditions during process development. However, model calibration remains a common bottlene...
Kinetics Calibration Chromatography, Ion Exchange Neural Networks, Computer Antibodies, Monoclonal
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Implementation of machine learning tool for continued process verification of process chromatography unit operation.

Journal of chromatography. A Dec 29, 2024
Recent advancements in technology, such as the emergence of artificial intelligence (AI) and machine learning (ML), have facilitated the progression of the biopharmaceutical industry toward the implementation of Industry 4.0. As per the guidelines se...
Machine Learning Spectrum Analysis, Raman Chromatography, Ion Exchange
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Application of artificial neural networks to predict multiple quality of dry-cured ham based on protein degradation.

Food chemistry Nov 9, 2020
This study investigated protein degradation and quality changes during the processing of dry-cured ham, and then established the multiple quality prediction model based on protein degradation. From the raw material to the curing period, proteolysis i...
Swine Color Chromatography, Ion Exchange Proteolysis Pork Meat Desiccation Amino Acids Neural Networks, Computer Animals
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Stability of infliximab solutions in different temperature and dilution conditions.

Journal of pharmaceutical and biomedical analysis Dec 18, 2017
Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the past few years, many studies have assessed that monoclonal antibodies are prone to aggregation under stress conditions. The aim of this study was to ...
Technology, Pharmaceutical Antirheumatic Agents Protein Aggregates Osmolar Concentration Infliximab Nanoparticles Pharmaceutical Solutions Biosimilar Pharmaceuticals Spectroscopy, Fourier Transform Infrared Temperature Drug Stability Spectrophotometry, Ultraviolet Chromatography, Ion Exchange Protein Stability Time Factors Drug Compounding Nephelometry and Turbidimetry Chromatography, Gel Peptide Mapping
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Microwave-assisted grafting polymerization modification of nylon 6 capillary-channeled polymer fibers for enhanced weak cation exchange protein separations.

Analytica chimica acta Dec 3, 2016
A weak cation exchange liquid chromatography stationary phase (nylon-COOH) was prepared by grafting polyacrylic acid on to native nylon 6 capillary-channeled polymer (C-CP) fibers via a microwave-assisted radical polymerization. To the best of our kn...
Reproducibility of Results Proteins Polymers Chromatography, Ion Exchange Antiporters Caprolactam Microwaves Polymerization
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Analytical Method for the Detection of Residual Active Ingredients Found in Neutralized Suspensions of Antimicrobial Products.

Journal of AOAC International Nov 10, 2016
An analytical method for determining the presence and levels of residual active ingredients found in neutralized suspensions of phenolic and quaternary ammonium salt-based antimicrobial products was developed using solid-phase extraction in combinati...
Dichlorophen Thiosulfates Tandem Mass Spectrometry Sodium Hypochlorite Benzalkonium Compounds Chromatography, Ion Exchange Culture Media Biphenyl Compounds Anti-Infective Agents Lipids Phenols
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Antioxidant and antiproliferative activities of protein hydrolysate from the rhizomes of Zingiberaceae plants.

Pakistan journal of pharmaceutical sciences Nov 1, 2016
Plant proteins have been investigated for their antioxidant activities, but there are still no reports detailing the antioxidant activity levels of plants in the Zingiberaceae family, which are popular food agents and used in folklore medicine. In th...
Rhizome Hep G2 Cells Dose-Response Relationship, Drug Ascorbic Acid Antioxidants Humans Zingiberaceae Biphenyl Compounds Plant Extracts Inhibitory Concentration 50 Antineoplastic Agents, Phytogenic Neoplasms Plants, Medicinal Picrates Cell Proliferation Phytotherapy Plant Proteins Protein Hydrolysates Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Molecular Weight Chromatography, Ion Exchange
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[Determination of trace and ultra-trace level bromate in water by large volume sample injection with enrichment column for on-line preconcentration coupled with ion chromatography].

Se pu = Chinese journal of chromatography Oct 1, 2015
A method for the determination of trace and ultra-trace level bromate in water by ion chromatography with large volume sample injection for on-line preconcentration was established. A high capacity Dionex IonPac AG23 guard column was simply used as t...
Bromates Drinking Water Chromatography, Ion Exchange
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