Automated cell nuclei segmentation is vital for the histopathological diagnosis of cancer. However, nuclei segmentation from 'hematoxylin and eosin' (HE) stained 'whole slide images' (WSIs) remains a challenge due to noise-induced intensity variation...
In higher eukaryotic cells, chromosomes are folded inside the nucleus. Recent advances in whole-genome mapping technologies have revealed the multiscale features of 3D genome organization that are intertwined with fundamental genome functions. Howeve...
BACKGROUND: We aimed to develop an artificial intelligence (AI)-assisted oral cytology method, similar to cervical cytology. We focused on the detection of cell nuclei because the ratio of cell nuclei to cytoplasm increases with increasing cell malig...
BACKGROUND: The segmentation of 3D cell nuclei is essential in many tasks, such as targeted molecular radiotherapies (MRT) for metastatic tumours, toxicity screening, and the observation of proliferating cells. In recent years, one popular method for...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2022
Accurate segmentation of nuclei is an essential step in analysis of digital histology images for diagnostic and prognostic applications. Despite recent advances in automated frameworks for nuclei segmentation, this task is still challenging. Specific...
Identification of nuclear components in the histology landscape is an important step towards developing computational pathology tools for the profiling of tumor micro-environment. Most existing methods for the identification of such components are li...
Neural networks : the official journal of the International Neural Network Society
Jul 1, 2022
Nuclei segmentation and classification of hematoxylin and eosin-stained histology images is a challenging task due to a variety of issues, such as color inconsistency that results from the non-uniform manual staining operations, clustering of nuclei,...
IEEE journal of biomedical and health informatics
Jul 1, 2022
Automated nuclei segmentation and classification are the keys to analyze and understand the cellular characteristics and functionality, supporting computer-aided digital pathology in disease diagnosis. However, the task still remains challenging due ...
IEEE journal of biomedical and health informatics
Jun 1, 2022
Cervical nucleus segmentation is a crucial and challenging issue in automatic pathological diagnosis due to uneven staining, blurry boundaries, and adherent or overlapping nuclei in nucleus images. To overcome the limitation of current methods, we pr...
The Journal of investigative dermatology
Jun 1, 2022
Image-based analysis as a method for mutation detection can be advantageous in settings when tumor tissue is limited or unavailable for direct testing. In this study, we utilize two distinct and complementary machine-learning methods of analyzing who...