AIMC Topic: CRISPR-Cas Systems

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[Application of machine learning in the CRISPR/Cas9 system].

Yi chuan = Hereditas
The third generation of the CRISPR/Cas9-mediated genome fixed-point editing technology has been widely used in the field of gene editing and gene expression regulation. How to improve the on-target efficiency and specificity of this system, as well a...

Off-target predictions in CRISPR-Cas9 gene editing using deep learning.

Bioinformatics (Oxford, England)
MOTIVATION: The prediction of off-target mutations in CRISPR-Cas9 is a hot topic due to its relevance to gene editing research. Existing prediction methods have been developed; however, most of them just calculated scores based on mismatches to the g...