Antibacterial drugs (AD) change the metabolic status of bacteria, contributing to bacterial death. However, antibiotic resistance and the emergence of multidrug-resistant bacteria increase interest in understanding metabolic network (MN) mutations an...
Nuclear magnetic resonance (NMR) spectroscopy is highly unbiased and reproducible, which provides us a powerful tool to analyze mixtures consisting of small molecules. However, the compound identification in NMR spectra of mixtures is highly challeng...
Physical and engineering sciences in medicine
May 30, 2022
Chest X-rays are arguably the de facto medical imaging technique for diagnosing thoracic abnormalities. Chest X-ray analysis is complex, especially in asymptomatic diseases, and relies heavily on the expertise of radiologists. This work proposes the ...
The ability to estimate the probability of a drug to receive approval in clinical trials provides natural advantages to optimizing pharmaceutical research workflows. Success rates of clinical trials have deep implications for costs, duration of devel...
Brazilian legal system prescribes means of ensuring the prompt processing of court cases, such as the principle of reasonable process duration, the principle of celerity, procedural economy, and due legal process, with a view to optimizing procedural...
INTRODUCTION: Coding medicinal products described on adverse event (AE) reports to specific entries in standardised drug dictionaries, such as WHODrug Global, is a time-consuming step in case processing activities despite its potential for automation...
With the rapid development of artificial intelligence (AI) technologies, and the large amount of pharmacovigilance-related data stored in an electronic manner, data-driven automatic methods need to be urgently applied to all aspects of pharmacovigila...
Increasing availability of electronic health databases capturing real-world experiences with medical products has garnered much interest in their use for pharmacoepidemiologic and pharmacovigilance studies. The traditional practice of having numerous...
BACKGROUND AND OBJECTIVE: Aim of nephrologists is to delay the outcome and reduce the number of patients undergoing renal failure (RF) by applying prevention protocols and accurately monitoring chronic kidney disease (CKD) patients. General practitio...
Journal of the American Society for Mass Spectrometry
May 11, 2022
Drug metabolite identification is a bottleneck of drug metabolism studies due to the need for time-consuming chromatographic separation and structural confirmation. Ion mobility-mass spectrometry (IM-MS), on the other hand, separates analytes on a ra...