AIMC Topic: DNA Contamination
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acdc - Automated Contamination Detection and Confidence estimation for single-cell genome data.
BMC bioinformatics
Dec 20, 2016
BACKGROUND: A major obstacle in single-cell sequencing is sample contamination with foreign DNA. To guarantee clean genome assemblies and to prevent the introduction of contamination into public databases, considerable quality control efforts are put...
Prediction of tumor purity from gene expression data using machine learning.
Briefings in bioinformatics
Nov 5, 2021
MOTIVATION: Bulk tumor samples used for high-throughput molecular profiling are often an admixture of cancer cells and non-cancerous cells, which include immune and stromal cells. The mixed composition can confound the analysis and affect the biologi...
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