AIMC Topic: DNA (Cytosine-5-)-Methyltransferases

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CDCA7 facilitates MET1-mediated CG DNA methylation maintenance in centromeric heterochromatin via linker histone H1.

Proceedings of the National Academy of Sciences of the United States of America Dec 10, 2025
DNA methylation is a conserved epigenetic modification essential for maintaining genome stability. However, how methyltransferases maintain CG methylation within compact chromatin, including centromeres, remains unclear. In humans, CDCA7 is necessary...
Humans DNA Methylation Mutation Histones DNA (Cytosine-5-)-Methyltransferases Arabidopsis Proteins Arabidopsis Centromere Heterochromatin
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Sensitive fluorescent detection of DNA methyltransferase using nicking endonuclease-mediated multiple primers-like rolling circle amplification.

Biosensors & bioelectronics Dec 30, 2016
Sensitive and reliable detection of DNA methyltransferase (MTase) is of great significance for both early tumor diagnosis and therapy. In this study, a simple, label-free and sensitive DNA MTase-sensing method was developed on the basis of a nicking ...
Humans DNA Primers Biosensing Techniques Nucleic Acid Amplification Techniques MCF-7 Cells DNA Spectrometry, Fluorescence HeLa Cells HEK293 Cells DNA (Cytosine-5-)-Methyltransferase 1 Enzyme Assays G-Quadruplexes DNA-Cytosine Methylases DNA (Cytosine-5-)-Methyltransferases Endonucleases
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