AIMC Topic: G-Quadruplexes
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Deep learning deciphers the related role of master regulators and G-quadruplexes in tissue specification.
Scientific reports
Jul 2, 2025
G-quadruplexes (GQs) are non-canonical DNA structures encoded by G-flipons with potential roles in gene regulation and chromatin structure. Here, we explore the role of G-flipons in tissue specification. We present a deep learning-based framework for...
Simple and Rapid Tumor EV Enrichment Enabled by Long DNA Probe-Guided Entanglement.
Angewandte Chemie (International ed. in English)
Jun 30, 2025
Specific subpopulations of extracellular vesicles (EVs) hold significant clinical potential for biomarker discovery, disease diagnosis, and therapeutic agents. However, this field remains underutilized due to the lack of straightforward and versatile...
Antifouling Capture and Dual-Targeting Recognition-Induced Signal Amplification for Triple-Mode Detection and Identification of Circulating Tumor Cells.
Analytical chemistry
Jun 12, 2025
Circulating tumor cells (CTCs) are promising biomarkers for cancer diagnosis, while detecting CTCs in clinical samples is still challenging due to the scarcity and heterogeneity of CTCs. Herein, a triple-mode sensing platform based on an antifouling ...
Loop Nucleotide Chemical Shifts as a Tool to Characterize DNA G-Quadruplexes.
Chemphyschem : a European journal of chemical physics and physical chemistry
May 7, 2025
DNA G-quadruplexes are known to play myriad functional roles in the cellular context and their structural diversity has diverse applications in various fields of science. Solution-state NMR spectroscopy has been instrumental in characterization of DN...
Rapid, portable, and sensitive detection of CaMV35S by RPA-CRISPR/Cas12a-G4 colorimetric assays with high accuracy deep learning object recognition and classification.
Talanta
Jun 20, 2024
Fast, sensitive, and portable detection of genetic modification contributes to agricultural security and food safety. Here, we developed RPA-CRISPR/Cas12a-G-quadruplex colorimetric assays that can combine with intelligent recognition by deep learning...
DeepG4: A deep learning approach to predict cell-type specific active G-quadruplex regions.
PLoS computational biology
Aug 12, 2021
DNA is a complex molecule carrying the instructions an organism needs to develop, live and reproduce. In 1953, Watson and Crick discovered that DNA is composed of two chains forming a double-helix. Later on, other structures of DNA were discovered an...
Insights into the Kinetic Partitioning Folding Dynamics of the Human Telomeric G-Quadruplex from Molecular Simulations and Machine Learning.
Journal of chemical theory and computation
Aug 25, 2020
The human telomeric DNA G-quadruplex follows a kinetic partitioning folding mechanism. The underlying folding landscape potentially has many minima separated by high free-energy barriers. However, using current theoretical models to characterize this...
Double-integrated mimic enzymes for the visual screening of Microcystin-LR: Copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme.
Analytica chimica acta
Dec 15, 2018
Recently, mimic enzymes have obtained particular interest by their high activity, stability, and biocompatibility. In this work, by coupling copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme to form a double-integrated mimic enzyme, a visual, ...
Integrating DNA structure switch with branched hairpins for the detection of uracil-DNA glycosylase activity and inhibitor screening.
Talanta
Nov 22, 2017
The detection of uracil-DNA glycosylase (UDG) activity is pivotal for its biochemical studies and the development of drugs for UDG-related diseases. Here, we explored an integrated DNA structure switch for high sensitive detection of UDG activity. Th...
Machine learning model for sequence-driven DNA G-quadruplex formation.
Scientific reports
Nov 6, 2017
We describe a sequence-based computational model to predict DNA G-quadruplex (G4) formation. The model was developed using large-scale machine learning from an extensive experimental G4-formation dataset, recently obtained for the human genome via G4...
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