Pathogenic (PEC) strains are important pathogens that causes a variety of infectious diseases in humans. Traditional bacterial culture and biochemical identification methods are time-consuming and lack specificity, making rapid and accurate diagnosi...
Angewandte Chemie (International ed. in English)
Nov 24, 2025
CRISPR/Cas12a-based detection of non-nucleic acid targets faces two major challenges: 1) limited sensitivity due to the inherent inability to pre-amplify non-nucleic acid targets, and 2) suboptimal performance of traditional reporters caused by photo...
As potential biomarkers for breast cancer, microRNAs (miRNAs) have demonstrated significant promise in clinical applications. However, accurate miRNA-based breast cancer diagnosis is hindered by the lack of simple, ultrasensitive, and highly specific...
Respiratory viral infections pose a significant global public health challenge, partly due to the difficulty in rapidly and accurately distinguishing between viruses with similar symptoms at the point of care, hindering timely and appropriate treatme...
The frequent global outbreaks of viral infectious diseases have significantly heightened the urgent demand for molecular testing at home. However, the labor-intensive sample preparation and nucleic acid amplification steps, along with the complexity ...
Digital nucleic acid amplification testing (dNAAT)-including digital PCR and isothermal techniques-has transformed precision diagnostics by enabling single-molecule quantification. However, its widespread adoption in point-of-care testing (POCT) rema...
INTRODUCTION: Early and accurate diagnosis of tuberculosis (TB) is central to ensuring the proper treatment and curbing the transmission of the disease. Despite the significant burden, the diagnosis of peripheral lymph node(LN)TB, the most prevalent ...
Nucleic-acid biosensors have emerged as useful tools for on-farm detection of foodborne pathogens on fresh produce. Such tools are specifically designed to be user-friendly so that a producer can operate them with minimal training and in a few simple...
Antibiotic-resistant bacteria pose considerable risks to global health, particularly through transmission in the food chain. Herein, we developed the artificial intelligence-driven quantification of antibiotic-resistant bacteria in food using a color...
AIMS: The visualization of nucleic acid testing (NAT) results plays a critical role in diagnosing and monitoring infectious and genetic diseases. The review aims to review the current status of AI-based NAT result visualization. It systematically int...
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